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Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.

Publication ,  Journal Article
Lubin, JH; Gaudet, MM; Olshan, AF; Kelsey, K; Boffetta, P; Brennan, P; Castellsague, X; Chen, C; Curado, MP; Dal Maso, L; Daudt, AW; Levi, F ...
Published in: Am J Epidemiol
June 15, 2010

Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.

Duke Scholars

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 15, 2010

Volume

171

Issue

12

Start / End Page

1250 / 1261

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Pharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Laryngeal Neoplasms
  • Humans
  • Epidemiology
  • Case-Control Studies
  • Body Mass Index
 

Citation

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Lubin, J. H., Gaudet, M. M., Olshan, A. F., Kelsey, K., Boffetta, P., Brennan, P., … Hayes, R. B. (2010). Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol, 171(12), 1250–1261. https://doi.org/10.1093/aje/kwq088
Lubin, Jay H., Mia M. Gaudet, Andrew F. Olshan, Karl Kelsey, Paolo Boffetta, Paul Brennan, Xavier Castellsague, et al. “Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.Am J Epidemiol 171, no. 12 (June 15, 2010): 1250–61. https://doi.org/10.1093/aje/kwq088.
Lubin JH, Gaudet MM, Olshan AF, Kelsey K, Boffetta P, Brennan P, et al. Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol. 2010 Jun 15;171(12):1250–61.
Lubin, Jay H., et al. “Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.Am J Epidemiol, vol. 171, no. 12, June 2010, pp. 1250–61. Pubmed, doi:10.1093/aje/kwq088.
Lubin JH, Gaudet MM, Olshan AF, Kelsey K, Boffetta P, Brennan P, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Lissowska J, Mates IN, Matos E, McClean M, Menezes A, Morgenstern H, Muscat J, Eluf Neto J, Purdue MP, Rudnai P, Schwartz SM, Shangina O, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn D, Zhang Z-F, Hashibe M, Hayes RB. Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol. 2010 Jun 15;171(12):1250–1261.
Journal cover image

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

June 15, 2010

Volume

171

Issue

12

Start / End Page

1250 / 1261

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Pharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Laryngeal Neoplasms
  • Humans
  • Epidemiology
  • Case-Control Studies
  • Body Mass Index