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Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population.

Publication ,  Journal Article
Wang, M; Wang, M; Zhang, W; Yuan, L; Fu, G; Wei, Q; Zhang, Z
Published in: Carcinogenesis
June 2009

A recent genome-wide association study identified two common variants that confer susceptibility to bladder cancer. We hypothesized that these variants are associated with risk of bladder cancer in Chinese populations. We genotyped rs9642880 G>T on 8q24 and rs710521 A>G on 3q28 in a two-stage case-control study of bladder cancer to evaluate the association and further examined the expression of MYC. We found that the rs9642880 G>T, but not the rs710521 A>G polymorphism, was associated with an increased risk of bladder cancer. Compared with the rs9642880 GG genotype, the GT/TT genotypes were associated with an odds ratio of 1.65 (95% confidence interval = 1.25-2.17), and this risk was more pronounced in young men and for low-risk tumors. Additional experiments revealed that the rs9642880 GT/TT genotypes were associated with enhanced levels of both MYC mRNA and protein in bladder tissues. Our findings suggested that the rs9642880 G>T polymorphism on 8q24 was independently associated with the risk of bladder cancer in Chinese populations.

Duke Scholars

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Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

June 2009

Volume

30

Issue

6

Start / End Page

991 / 996

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Risk
  • RNA, Messenger
  • Proto-Oncogene Proteins c-myc
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
 

Citation

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Wang, M., Zhang, W., Yuan, L., Fu, G., Wei, Q., & Zhang, Z. (2009). Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population. Carcinogenesis, 30(6), 991–996. https://doi.org/10.1093/carcin/bgp091
Wang, Meilin, Miaomiao Wang, Wei Zhang, Lin Yuan, Guangbo Fu, Qingyi Wei, and Zhengdong Zhang. “Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population.Carcinogenesis 30, no. 6 (June 2009): 991–96. https://doi.org/10.1093/carcin/bgp091.
Wang M, Zhang W, Yuan L, Fu G, Wei Q, Zhang Z. Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population. Carcinogenesis. 2009 Jun;30(6):991–6.
Wang, Meilin, et al. “Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population.Carcinogenesis, vol. 30, no. 6, June 2009, pp. 991–96. Pubmed, doi:10.1093/carcin/bgp091.
Wang M, Zhang W, Yuan L, Fu G, Wei Q, Zhang Z. Common genetic variants on 8q24 contribute to susceptibility to bladder cancer in a Chinese population. Carcinogenesis. 2009 Jun;30(6):991–996.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

June 2009

Volume

30

Issue

6

Start / End Page

991 / 996

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Risk
  • RNA, Messenger
  • Proto-Oncogene Proteins c-myc
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study