Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.


Journal Article

Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated the roles of both genetic susceptibility and smoking history in the initiation, clonal expansion, and malignant transformation processes in lung carcinogenesis, integrating information collected by a case-control study and a large-scale prospective cohort study. Our results show that individuals with suboptimal DNA repair capacity have enhanced transition rates of key events in carcinogenesis.

Full Text

Duke Authors

Cited Authors

  • Deng, L; Kimmel, M; Foy, M; Spitz, M; Wei, Q; Gorlova, O

Published Date

  • May 1, 2009

Published In

Volume / Issue

  • 124 / 9

Start / End Page

  • 2152 - 2158

PubMed ID

  • 19123470

Pubmed Central ID

  • 19123470

Electronic International Standard Serial Number (EISSN)

  • 1097-0215

Digital Object Identifier (DOI)

  • 10.1002/ijc.24149


  • eng

Conference Location

  • United States