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The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

Publication ,  Journal Article
Guan, X; Zhao, H; Niu, J; Tang, D; Ajani, JA; Wei, Q
Published in: BMC Gastroenterol
October 16, 2009

BACKGROUND: Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population. METHODS: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity. RESULTS: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer. CONCLUSION: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.

Duke Scholars

Published In

BMC Gastroenterol

DOI

EISSN

1471-230X

Publication Date

October 16, 2009

Volume

9

Start / End Page

77

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta1
  • Stomach Neoplasms
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Haplotypes
 

Citation

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Guan, X., Zhao, H., Niu, J., Tang, D., Ajani, J. A., & Wei, Q. (2009). The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol, 9, 77. https://doi.org/10.1186/1471-230X-9-77
Guan, Xiaoxiang, Hui Zhao, Jiangong Niu, Dongfeng Tang, Jaffer A. Ajani, and Qingyi Wei. “The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.BMC Gastroenterol 9 (October 16, 2009): 77. https://doi.org/10.1186/1471-230X-9-77.
Guan X, Zhao H, Niu J, Tang D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol. 2009 Oct 16;9:77.
Guan, Xiaoxiang, et al. “The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.BMC Gastroenterol, vol. 9, Oct. 2009, p. 77. Pubmed, doi:10.1186/1471-230X-9-77.
Guan X, Zhao H, Niu J, Tang D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol. 2009 Oct 16;9:77.
Journal cover image

Published In

BMC Gastroenterol

DOI

EISSN

1471-230X

Publication Date

October 16, 2009

Volume

9

Start / End Page

77

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta1
  • Stomach Neoplasms
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Haplotypes