Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population.


Journal Article

One-carbon metabolism facilitates the cross-talk between genetic and epigenetic processes, making it a good candidate for studying the risk of lung cancer. To investigate the role of common variants of one-carbon metabolizing genes on lung cancer risk, total 25 single nucleotide polymorphisms (SNPs) in 7 genes were genotyped among 500 incident lung cancer patients and 517 cancer-free controls. An increased risk was suggested for the variant allele carriers of MTHFR rs17037396 [odds ratio (OR)=1.39, 95% confidence interval (CI): 1.00-1.94] and rs3753584 (OR=1.46, 95% CI: 1.03-2.08), compared with subjects with wild homozygote, respectively, and the risk was more pronounced among older individuals (>60 years). In contrast, a decreased risk was observed for TYMS rs2853742 variant allele carriers (OR=0.44, 95% CI: 0.19-0.99) and MTHFD rs2236225 variant allele carriers (OR=0.76, 95% CI: 0.59-0.99). Haplotype analysis revealed that MTHFR "ACCACC" haplotype may contribute to the risk of lung cancer (OR=1.49, 95% CI: 1.03-2.14, local test p value 0.032). A data mining method, multifactor dimensionality reduction (MDR), predicted a four-factor interaction model (rs1801133, rs4659731, rs2273029 and rs699517) with the lowest average prediction error (45.08%, p<0.001). These findings suggest that genetic variants in one-carbon metabolizing genes might modulate the risk of lung cancer. Validation of these findings in larger studies is needed.

Full Text

Duke Authors

Cited Authors

  • Liu, H; Jin, G; Wang, H; Wu, W; Liu, Y; Qian, J; Fan, W; Ma, H; Miao, R; Hu, Z; Sun, W; Wang, Y; Jin, L; Wei, Q; Shen, H; Huang, W; Lu, D

Published Date

  • July 2008

Published In

Volume / Issue

  • 61 / 1

Start / End Page

  • 21 - 29

PubMed ID

  • 18221821

Pubmed Central ID

  • 18221821

International Standard Serial Number (ISSN)

  • 0169-5002

Digital Object Identifier (DOI)

  • 10.1016/j.lungcan.2007.12.001


  • eng

Conference Location

  • Ireland