DNA repair capacity and lung cancer risk in never smokers.
Journal Article (Journal Article)
Besides secondhand smoke exposure, few other risk factors for lung cancer in lifetime never smokers have been identified. We present the estimates of lung cancer risk associated with suboptimal DNA repair capacity (DRC) measured by the host-cell reactivation assay in lifetime never smokers using data from 219 cases and 309 matched controls enrolled in a case-control study. Suboptimal DRC level (below the control median) conferred a significantly increased lung cancer risk in never smokers [odds ratio, 1.92; 95% confidence interval (95% CI), 1.3-2.9; P = 0.0024]. There was a 3.38-fold risk for individuals with DRC below the first quartile (95% CI, 1.8-6.3) compared with individuals with DRC above the third quartile. Secondhand smoke exposure in individuals with DRC below the control median was associated with a 3.81-fold risk of lung cancer (95% CI, 2.3-6.4). A 2.49-fold (95% CI, 1.1-5.6) risk was noted for the joint effects of lung cancer family history in first-degree relatives and suboptimal DRC. Relatives of probands (cases and controls) with lowest DRC (below the first quartile) were significantly more likely to be diagnosed with lung cancer (odds ratio, 2.69; 95% CI, 1.1-6.7) compared with relatives of probands with the most proficient DRC (above the third quartile). Relatives of probands with suboptimal (below the control median) versus proficient DRC also had an earlier age at diagnosis with lung cancer, although the only statistically significant difference was in female relatives (55.4 versus 67.7 years; P = 0.03).
Full Text
Duke Authors
Cited Authors
- Gorlova, OY; Weng, S-F; Zhang, Y; Amos, CI; Spitz, MR; Wei, Q
Published Date
- June 2008
Published In
Volume / Issue
- 17 / 6
Start / End Page
- 1322 - 1328
PubMed ID
- 18559546
Pubmed Central ID
- PMC6587178
International Standard Serial Number (ISSN)
- 1055-9965
Digital Object Identifier (DOI)
- 10.1158/1055-9965.EPI-07-2591
Language
- eng
Conference Location
- United States