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Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.

Publication ,  Journal Article
Ho, T; Li, G; Zhao, C; Zheng, R; Wei, Q; Sturgis, EM
Published in: Head Neck
March 2008

BACKGROUND: The purpose of this study was to examine the association between 4 Fas single nucleotide polymorphisms (SNPs) and risk of differentiated thyroid carcinoma (DTC) and salivary gland carcinoma (SGC). METHODS: We conducted a case-control study including 279 DTC cases, 165 benign thyroid disease (BTD) cases, 154 SGC cases, 61 benign salivary gland disease (BSGD) cases, and 510 controls. RESULTS: The A744G SNP genotype distribution was significantly different between subjects with SGC or BSGD and controls, while that of the A18272G SNP was significantly different between subjects with DTC or SGC and controls. Risk of SGC was significantly elevated for the 22628 heterozygous CT genotype (odds ratio [OR] = 1.5, p = .050), and risk of BSGD was elevated for the 22628 homozygous TT genotype (OR = 2.9, p = .023). CONCLUSION: Fas C22628T SNP may be associated with risk of SGC and BSGD, but none of the investigated Fas SNPs was associated with risk of DTC.

Duke Scholars

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

March 2008

Volume

30

Issue

3

Start / End Page

297 / 305

Location

United States

Related Subject Headings

  • fas Receptor
  • Thyroid Neoplasms
  • Thyroid Diseases
  • Salivary Gland Neoplasms
  • Salivary Gland Diseases
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Otorhinolaryngology
  • Middle Aged
  • Male
 

Citation

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Chicago
ICMJE
MLA
NLM
Ho, T., Li, G., Zhao, C., Zheng, R., Wei, Q., & Sturgis, E. M. (2008). Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis. Head Neck, 30(3), 297–305. https://doi.org/10.1002/hed.20699
Ho, Tang, Guojun Li, Chong Zhao, Rong Zheng, Qingyi Wei, and Erich M. Sturgis. “Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.Head Neck 30, no. 3 (March 2008): 297–305. https://doi.org/10.1002/hed.20699.
Ho T, Li G, Zhao C, Zheng R, Wei Q, Sturgis EM. Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis. Head Neck. 2008 Mar;30(3):297–305.
Ho, Tang, et al. “Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis.Head Neck, vol. 30, no. 3, Mar. 2008, pp. 297–305. Pubmed, doi:10.1002/hed.20699.
Ho T, Li G, Zhao C, Zheng R, Wei Q, Sturgis EM. Fas single nucleotide polymorphisms and risk of thyroid and salivary gland carcinomas: a case-control analysis. Head Neck. 2008 Mar;30(3):297–305.
Journal cover image

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

March 2008

Volume

30

Issue

3

Start / End Page

297 / 305

Location

United States

Related Subject Headings

  • fas Receptor
  • Thyroid Neoplasms
  • Thyroid Diseases
  • Salivary Gland Neoplasms
  • Salivary Gland Diseases
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Otorhinolaryngology
  • Middle Aged
  • Male