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Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.

Publication ,  Journal Article
Liu, H; Jin, G; Wang, H; Wu, W; Liu, Y; Qian, J; Fan, W; Ma, H; Miao, R; Hu, Z; Sun, W; Wang, Y; Jin, L; Wei, Q; Shen, H; Huang, W; Lu, D
Published in: Biomarkers
September 2008

Polymorphisms of the methyl-CpG binding domain 1 (MBD1) gene may influence MBD1 activity on gene expression profiles, thereby modulating individual susceptibility to lung cancer. To test this hypothesis, we investigated the associations of four MBD1 polymorphisms and lung cancer risk in a Chinese population. Single locus analysis revealed significant associations between two polymorphisms (rs125555 and rs140689) and lung cancer risk (p=0.011 and p=0.005, respectively). Since the two polymorphisms were in linkage disequilibrium, further haplotype analyses were performed and revealed a significant association with lung cancer (global test p-value=0.0041). Our results suggested that MBD1 polymorphisms might be involved in the development of lung cancer. Validation of these findings in larger studies of other populations is needed.

Duke Scholars

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

September 2008

Volume

13

Issue

6

Start / End Page

607 / 617

Location

England

Related Subject Headings

  • Transcription Factors
  • Toxicology
  • Smoking
  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Liu, H., Jin, G., Wang, H., Wu, W., Liu, Y., Qian, J., … Lu, D. (2008). Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Biomarkers, 13(6), 607–617. https://doi.org/10.1080/13547500802168031
Liu, Hongliang, Guangfu Jin, Haifeng Wang, Wenting Wu, Yanhong Liu, Ji Qian, Weiwei Fan, et al. “Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.Biomarkers 13, no. 6 (September 2008): 607–17. https://doi.org/10.1080/13547500802168031.
Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, et al. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Biomarkers. 2008 Sep;13(6):607–17.
Liu, Hongliang, et al. “Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.Biomarkers, vol. 13, no. 6, Sept. 2008, pp. 607–17. Pubmed, doi:10.1080/13547500802168031.
Liu H, Jin G, Wang H, Wu W, Liu Y, Qian J, Fan W, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W, Lu D. Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. Biomarkers. 2008 Sep;13(6):607–617.
Journal cover image

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

September 2008

Volume

13

Issue

6

Start / End Page

607 / 617

Location

England

Related Subject Headings

  • Transcription Factors
  • Toxicology
  • Smoking
  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Middle Aged
  • Male
  • Lung Neoplasms