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Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.

Publication ,  Journal Article
An, Y; Jin, G; Wang, H; Wang, Y; Liu, H; Li, R; Wang, H; Qian, J; Sun, W; Ma, H; Miao, R; Hu, Z; Jin, L; Wei, Q; Shen, H; Huang, W; Lu, D
Published in: Lung Cancer
February 2008

DNA mismatch repair (MMR) plays an important role in maintaining genome stability. Defects in MMR genes have been involved in several types of sporadic and hereditary cancers. hMLH1 is considered one of central members of the MMR pathway. We conducted a hospital-based case-control study to investigate associations of common variations in the hMLH1 gene and risk of lung cancer. A total of 500 cases and 517 controls were genotyped for seven SNPs in hMLH1. Overall, the rs1799977 I219V polymorphism was marginally associated with the risk of lung cancer (P=0.055). This association was much stronger in younger patients (P=0.01; odds ratio, 5.28; 95% CI 1.45-19.21) and lung squamous cell carcinoma (P=0.006; odds ratio, 3.65; 95% CI 1.44-9.24). These findings indicate that the hMLH1 rs1799977 polymorphism may contribute to the etiology of early-onset lung cancer as well as some specific subtype of lung cancer. Larger association studies are warranted to validate our findings and mechanistic studies are needed to elucidate the underlying molecular mechanisms of the association.

Duke Scholars

Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

February 2008

Volume

59

Issue

2

Start / End Page

164 / 170

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • MutL Protein Homolog 1
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
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An, Y., Jin, G., Wang, H., Wang, Y., Liu, H., Li, R., … Lu, D. (2008). Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer, 59(2), 164–170. https://doi.org/10.1016/j.lungcan.2007.08.003
An, Yu, Guangfu Jin, Haifeng Wang, Yi Wang, Hongliang Liu, Rui Li, Haijian Wang, et al. “Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.Lung Cancer 59, no. 2 (February 2008): 164–70. https://doi.org/10.1016/j.lungcan.2007.08.003.
An Y, Jin G, Wang H, Wang Y, Liu H, Li R, et al. Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer. 2008 Feb;59(2):164–70.
An, Yu, et al. “Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population.Lung Cancer, vol. 59, no. 2, Feb. 2008, pp. 164–70. Pubmed, doi:10.1016/j.lungcan.2007.08.003.
An Y, Jin G, Wang H, Wang Y, Liu H, Li R, Qian J, Sun W, Ma H, Miao R, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D. Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population. Lung Cancer. 2008 Feb;59(2):164–170.
Journal cover image

Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

February 2008

Volume

59

Issue

2

Start / End Page

164 / 170

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • MutL Protein Homolog 1
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Incidence