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Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population.

Publication ,  Journal Article
Shao, M; Ma, H; Wang, Y; Xu, L; Yuan, J; Wang, Y; Hu, Z; Yang, L; Wang, F; Liu, H; Qian, J; Xun, P; Chen, W; Yuan, W; Jing, G; Chen, F ...
Published in: Lung Cancer
June 2008

ERCC4/XPF protein plays an important role in the nucleotide excision repair (NER) pathway, and deficiencies in the gene encoding it can lead to a repair-deficiency syndrome, xeroderma pigmentosum group F (XP-F). Common variants on this gene are assumed to be foreboding markers for lung cancer, and 4 selected SNPs in the ERCC4 gene were genotyped in a multi-center case-control study involving 1010 lung cancer patients and 1011 cancer-free controls in a Chinese Han population to test the hypothesis. A significant association to decreased risk of lung cancer was observed in major allele C of rs3136038 carriers (adjusted OR=0.57, 95% CI=0.39-0.84 for CT; adjusted OR=0.75, 95% CI=0.52-1.10 for CC; adjusted OR=0.68, 95% CI=0.46-0.99 for CT+CC, compared with genotype TT), and additionally, referenced with homozygote TT, the heterozygous genotype CT showed a distinct protective effect in younger subjects (adjusted OR=0.47, 95% CI=0.26-0.86), in males (adjusted OR=0.59, 95% CI=0.37-0.93), in non-smokers (adjusted OR=0.38, 95% CI=0.20-0.72), in subjects without family history of cancer (adjusted OR=0.52, 95% CI=0.34-0.80) and in adenocarcinomas patients (adjusted OR=0.51, 95% CI=0.31-0.84). Our finding indicated, for the first time, the polymorphism rs3136038 on the promotor region of ERCC4 may contribute to the etiology of lung cancer. Further functional studies on this locus and/or other genetic variants in highly linkage disequilibrium with it are warranted to elucidate the underlying molecular mechanisms of the association.

Duke Scholars

Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

June 2008

Volume

60

Issue

3

Start / End Page

332 / 339

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Linkage Disequilibrium
  • Humans
 

Citation

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Shao, M., Ma, H., Wang, Y., Xu, L., Yuan, J., Hu, Z., … Lu, D. (2008). Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. Lung Cancer, 60(3), 332–339. https://doi.org/10.1016/j.lungcan.2007.10.023
Shao, Minhua, Hongxia Ma, Ying Wang, Liang Xu, Jing Yuan, Yi Wang, Zhibin Hu, et al. “Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population.Lung Cancer 60, no. 3 (June 2008): 332–39. https://doi.org/10.1016/j.lungcan.2007.10.023.
Shao, Minhua, et al. “Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population.Lung Cancer, vol. 60, no. 3, June 2008, pp. 332–39. Pubmed, doi:10.1016/j.lungcan.2007.10.023.
Shao M, Ma H, Wang Y, Xu L, Yuan J, Hu Z, Yang L, Wang F, Liu H, Qian J, Xun P, Chen W, Yuan W, Jing G, Chen F, Jin L, Wei Q, Wu T, Shen H, Huang W, Lu D. Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. Lung Cancer. 2008 Jun;60(3):332–339.
Journal cover image

Published In

Lung Cancer

DOI

ISSN

0169-5002

Publication Date

June 2008

Volume

60

Issue

3

Start / End Page

332 / 339

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Linkage Disequilibrium
  • Humans