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Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.

Publication ,  Journal Article
Koshkina, NV; Kleinerman, ES; Li, G; Zhao, CC; Wei, Q; Sturgis, EM
Published in: J Pediatr Hematol Oncol
December 2007

Defective apoptosis signaling by the Fas pathway has carcinogenic implications. We analyzed 123 pediatric patients with osteosarcoma for Fas single nucleotide polymorphisms: 2 of the promoter region (-1377 G>A and -670 A>G) and 2 of the coding region (exon 3 18272 A>G and exon 7 22628 C>T). As a comparison group, we used 510 adults without a history of cancer. We found an increased risk of osteosarcoma associated with the heterozygous genotype Fas exon 3 AG (genotype frequency 19.5% in cases vs. 12.0% in controls, P=0.028; adjusted odds ratio=1.6, 95% confidence interval=0.9-2.7], and this association was more pronounced in non-Hispanic whites (20.6% in cases vs. 10.1% in controls, P=0.014; adjusted odds ratio=2.3, 95% confidence interval=1.2-4.6). Additionally, the frequency of the variant allele (exon 3 G) was significantly higher in cases than in controls for both the entire group and non-Hispanic whites (P=0.046 and P=0.030, respectively). We found no significant association between osteosarcoma risk and the other Fas polymorphisms. This study suggests an association between the Fas exon 3 A>G polymorphism and osteosarcoma risk; however, further study is needed with pediatric controls and a larger sample size.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

ISSN

1077-4114

Publication Date

December 2007

Volume

29

Issue

12

Start / End Page

815 / 821

Location

United States

Related Subject Headings

  • fas Receptor
  • Reference Values
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

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Koshkina, N. V., Kleinerman, E. S., Li, G., Zhao, C. C., Wei, Q., & Sturgis, E. M. (2007). Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. J Pediatr Hematol Oncol, 29(12), 815–821. https://doi.org/10.1097/MPH.0b013e3181581506
Koshkina, Nadezhda V., Eugenie S. Kleinerman, Guojun Li, Chong C. Zhao, Qingyi Wei, and Erich M. Sturgis. “Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.J Pediatr Hematol Oncol 29, no. 12 (December 2007): 815–21. https://doi.org/10.1097/MPH.0b013e3181581506.
Koshkina NV, Kleinerman ES, Li G, Zhao CC, Wei Q, Sturgis EM. Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. J Pediatr Hematol Oncol. 2007 Dec;29(12):815–21.
Koshkina, Nadezhda V., et al. “Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients.J Pediatr Hematol Oncol, vol. 29, no. 12, Dec. 2007, pp. 815–21. Pubmed, doi:10.1097/MPH.0b013e3181581506.
Koshkina NV, Kleinerman ES, Li G, Zhao CC, Wei Q, Sturgis EM. Exploratory analysis of Fas gene polymorphisms in pediatric osteosarcoma patients. J Pediatr Hematol Oncol. 2007 Dec;29(12):815–821.

Published In

J Pediatr Hematol Oncol

DOI

ISSN

1077-4114

Publication Date

December 2007

Volume

29

Issue

12

Start / End Page

815 / 821

Location

United States

Related Subject Headings

  • fas Receptor
  • Reference Values
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Humans
  • Genotype
  • Genetic Predisposition to Disease