Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study.

Journal Article (Journal Article)

BACKGROUND: The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage. Because mutations in XPC cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer. METHODS: In this hospital-based case-control study, we investigated five XPC tagging, common single nucleotide polymorphisms (tagging SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer free controls in a Chinese population. RESULTS: In individual tagging SNP analysis, we found that rs3731055AG+AA variant genotypes were associated with a significantly decreased risk of lung adenocarcinoma [adjusted odds ratio (OR), 0.71; 95% confidence interval (CI), 0.56-0.90] but an increased risk of small cell carcinomas [adjusted OR, 1.79; 95% CI, 1.05-3.07]. Furthermore, we found that haplotype ACCCA was associated with a decreased risk of lung adenocarcinoma [OR, 0.78; 95% CI, 0.62-0.97] but an increased risk of small cell carcinomas [OR, 1.68; 95% CI, 1.04-2.71], which reflected the presence of rs3731055A allele in this haplotype. Further stratified analysis revealed that the protective effect of rs3731055AG+AA on risk of lung adenocarcinoma was more evident among young subjects (age < or= 60) and never smokers. CONCLUSION: These results suggest that inherited sequence variations in XPC may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations. However, these findings need to be verified in larger confirmatory studies with more comprehensively selected tagging SNPs.

Full Text

Duke Authors

Cited Authors

  • Bai, Y; Xu, L; Yang, X; Hu, Z; Yuan, J; Wang, F; Shao, M; Yuan, W; Qian, J; Ma, H; Wang, Y; Liu, H; Chen, W; Yang, L; Jing, G; Huo, X; Chen, F; Liu, Y; Jin, L; Wei, Q; Huang, W; Shen, H; Lu, D; Wu, T

Published Date

  • May 13, 2007

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 81 -

PubMed ID

  • 17498315

Pubmed Central ID

  • PMC1884164

Electronic International Standard Serial Number (EISSN)

  • 1471-2407

Digital Object Identifier (DOI)

  • 10.1186/1471-2407-7-81


  • eng

Conference Location

  • England