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Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population.

Publication ,  Journal Article
Wang, H; Hao, B; Chen, X; Zhao, N; Cheng, G; Jiang, Y; Liu, Y; Lin, C; Tan, W; Lu, D; Wei, Q; Jin, L; Lin, D; He, F
Published in: Cancer Lett
August 28, 2006

The incidence of lung adenocarcinoma (AC) has been increasing over recent decades. The tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the most potent carcinogens and reproducibly induces a high incidence of lung AC in laboratory animals. In addition to its genotoxic effects, NNK has also epigenetic effects on lung cells by functioning as an agonist for beta adrenergic receptors and stimulating the signal pathways that lead to lung AC. Beta-2 adrenergic receptor (ADRB2) expressed on bronchial smooth muscle is a well-defined target for asthma treatment that has epidemiological implications in lung cancer development. And biochemical effect and pharmacogenetic relevance of regulatory and coding variants of ADRB2 have been well documented. Aiming to test whether the genetic variants of ADRB2 modify risk of lung AC, we compared the manifestation of three common single nucleotide polymorphisms (SNPs) of ADRB2 (G-1023A, G-654A, and A46G (Gly16Arg)) between 313 patients with lung AC and 321 controls. Overall association was not observed between risk and either individual of the three SNPs or their combined haplotypes. However, in the subgroup of young subjects < or =50 years old, significant association was observed for G-1023A (allele based OR, 1.82; 95% CI, 1.12-2.95), A46G (Gly16Arg) (allele based OR, 0.64; 95% CI, 0.40-1.03), and the haplotype A(-1023)A(46) (OR 2.62; 95% CI 1.30-5.27). Our results do not support a major independent role of ADRB2 polymorphisms in lung AC risk, suggesting that functional variants of other genes involved in the NNK epigenetic pathway of carcinogenesis should be investigated.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

August 28, 2006

Volume

240

Issue

2

Start / End Page

297 / 305

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Receptors, Adrenergic, beta-2
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Haplotypes
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, H., Hao, B., Chen, X., Zhao, N., Cheng, G., Jiang, Y., … He, F. (2006). Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. Cancer Lett, 240(2), 297–305. https://doi.org/10.1016/j.canlet.2005.09.018
Wang, Haijian, Bingtao Hao, Xiaoping Chen, Naiqing Zhao, Gang Cheng, Yan Jiang, Yang Liu, et al. “Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population.Cancer Lett 240, no. 2 (August 28, 2006): 297–305. https://doi.org/10.1016/j.canlet.2005.09.018.
Wang H, Hao B, Chen X, Zhao N, Cheng G, Jiang Y, et al. Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. Cancer Lett. 2006 Aug 28;240(2):297–305.
Wang, Haijian, et al. “Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population.Cancer Lett, vol. 240, no. 2, Aug. 2006, pp. 297–305. Pubmed, doi:10.1016/j.canlet.2005.09.018.
Wang H, Hao B, Chen X, Zhao N, Cheng G, Jiang Y, Liu Y, Lin C, Tan W, Lu D, Wei Q, Jin L, Lin D, He F. Beta-2 adrenergic receptor gene (ADRB2) polymorphism and risk for lung adenocarcinoma: a case-control study in a Chinese population. Cancer Lett. 2006 Aug 28;240(2):297–305.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

August 28, 2006

Volume

240

Issue

2

Start / End Page

297 / 305

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Receptors, Adrenergic, beta-2
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Haplotypes