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Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.

Publication ,  Journal Article
Li, C; Wu, W; Liu, J; Qian, L; Li, A; Yang, K; Wei, Q; Zhou, J; Zhang, Z
Published in: Pharmacogenet Genomics
April 2006

BACKGROUND: FAS and FASLG together initiate apoptosis, which prevents tumor development. FAS and FASLG polymorphisms in the promoter regions can alter the transcriptional activities and thus alter risk of cancer. We hypothesized that the FAS -1377G>A, -670A>G, and FASLG -844T>C polymorphisms are associated with risk of bladder cancer. METHODS: In a hospital-based case-control study of 216 case patients with newly diagnosed bladder transitional cell carcinoma and 252 cancer-free controls frequency-matched by age and sex, we genotyped polymorphisms using PCR-restriction fragment length polymorphism. RESULTS: We found a statistically significantly increased risk of bladder cancer associated with the FASLG -844CC genotype [adjusted OR=1.51; 95% CI 1.03-2.23] compared with -844 (CT+TT). Consistently, the FAS haplotype genotypes with 2-4 variant (risk) alleles (-1377A and -670A) were associated with an increased risk of bladder cancer compared to 0-1 variants (OR=2.14; 95% CI 1.10-4.16). Furthermore, when we evaluated these three polymorphisms together, we found that the combined genotypes with 4-6 variant (risk) alleles (-1377A, -670A, and -844C) were associated with an increased risk of bladder cancer (OR=1.58; 95% CI 1.07-2.34) compared to 1-3 variants, and this increased risk was more pronounced among subgroups of aged >50 years (OR=1.70; 95% CI 1.11-2.61) and smokers (OR=1.88; 95% CI 1.06-3.32). CONCLUSIONS: FAS and FASLG polymorphisms appear to jointly contribute to risk of bladder cancer in this southern Chinese population. Larger studies are needed to verify these findings.

Duke Scholars

Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

April 2006

Volume

16

Issue

4

Start / End Page

245 / 251

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tumor Necrosis Factors
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Pharmacology & Pharmacy
  • Odds Ratio
  • Molecular Epidemiology
  • Middle Aged
  • Membrane Glycoproteins
 

Citation

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Li, C., Wu, W., Liu, J., Qian, L., Li, A., Yang, K., … Zhang, Z. (2006). Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. Pharmacogenet Genomics, 16(4), 245–251. https://doi.org/10.1097/01.fpc.0000194425.58511.a7
Li, Chunping, Wei Wu, Jia Liu, Lixin Qian, Aiping Li, Kehu Yang, Qingyi Wei, Jianwei Zhou, and Zhengdong Zhang. “Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.Pharmacogenet Genomics 16, no. 4 (April 2006): 245–51. https://doi.org/10.1097/01.fpc.0000194425.58511.a7.
Li, Chunping, et al. “Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.Pharmacogenet Genomics, vol. 16, no. 4, Apr. 2006, pp. 245–51. Pubmed, doi:10.1097/01.fpc.0000194425.58511.a7.
Li C, Wu W, Liu J, Qian L, Li A, Yang K, Wei Q, Zhou J, Zhang Z. Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. Pharmacogenet Genomics. 2006 Apr;16(4):245–251.

Published In

Pharmacogenet Genomics

DOI

ISSN

1744-6872

Publication Date

April 2006

Volume

16

Issue

4

Start / End Page

245 / 251

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tumor Necrosis Factors
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Pharmacology & Pharmacy
  • Odds Ratio
  • Molecular Epidemiology
  • Middle Aged
  • Membrane Glycoproteins