Skip to main content
Journal cover image

Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.

Publication ,  Journal Article
Hu, Z; Ma, H; Lu, D; Qian, J; Zhou, J; Chen, Y; Xu, L; Wang, X; Wei, Q; Shen, H
Published in: Int J Cancer
March 1, 2006

Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53-response promoter, and the other is a 40-bp insertion/deletion polymorphism in the constitutive promoter) were identified, and recently the T/G substitution (SNP309) has been demonstrated to alter the levels of MDM2 gene products. In this molecular epidemiological study with 717 incident lung cancer cases and 1,083 cancer-free controls, we genotyped these 2 promoter polymorphisms of MDM2 and evaluated their associations with risk of lung cancer. We found that there were no significant associations between MDM2 SNP309 variant genotypes and lung cancer risk (adjusted OR = 1.20, 95% CI = 0.95-1.53 for TG and adjusted OR = 1.12, 95% CI = 0.85-1.48 for GG, respectively). Similarly, we did not find evidence for any association between risk of lung cancer and MDM2 insertion/deletion polymorphism. The findings suggest that these two MDM2 promoter polymorphisms may not play a major role in lung cancer susceptibility in this Chinese population.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

March 1, 2006

Volume

118

Issue

5

Start / End Page

1275 / 1278

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, Z., Ma, H., Lu, D., Qian, J., Zhou, J., Chen, Y., … Shen, H. (2006). Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. Int J Cancer, 118(5), 1275–1278. https://doi.org/10.1002/ijc.21463
Hu, Zhibin, Hongxia Ma, Daru Lu, Ji Qian, Jiannong Zhou, Yijiang Chen, Lin Xu, Xinru Wang, Qingyi Wei, and Hongbing Shen. “Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.Int J Cancer 118, no. 5 (March 1, 2006): 1275–78. https://doi.org/10.1002/ijc.21463.
Hu Z, Ma H, Lu D, Qian J, Zhou J, Chen Y, et al. Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. Int J Cancer. 2006 Mar 1;118(5):1275–8.
Hu, Zhibin, et al. “Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.Int J Cancer, vol. 118, no. 5, Mar. 2006, pp. 1275–78. Pubmed, doi:10.1002/ijc.21463.
Hu Z, Ma H, Lu D, Qian J, Zhou J, Chen Y, Xu L, Wang X, Wei Q, Shen H. Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. Int J Cancer. 2006 Mar 1;118(5):1275–1278.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

March 1, 2006

Volume

118

Issue

5

Start / End Page

1275 / 1278

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female