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MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.

Publication ,  Journal Article
Li, G; Zhai, X; Zhang, Z; Chamberlain, RM; Spitz, MR; Wei, Q
Published in: Carcinogenesis
October 2006

The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promoter polymorphisms are associated with risk of lung cancer, we conducted a hospital-based, case-control study of 1026 non-Hispanic white patients newly diagnosed with lung cancer and 1145 cancer-free controls who were frequency-matched by age (+/-5 years), sex, ethnicity and smoking status. We genotyped for the MDM2 promoter G2580T (also called SNP309) and G2164A polymorphisms that have a minor allele frequency >0.05. The distributions of the MDM2-2580G variant allele and genotypes were significantly less common among the cases than among the controls (P = 0.038 and 0.045, respectively), but this was not evident for MDM2-2164G (P = 0.865 and 0.614, respectively). Compared with the MDM2-2580TT genotype, the MDM2-2580G variant genotypes were associated with a decreased risk of lung cancer [odds ratio = 0.81 and 95% confidence interval = 0.67-0.98 for GT, 0.83 (0.63-1.08) for GG, and 0.81 (0.68-0.97) for the combined GT/GG genotype]. However, no significant association was observed between the MDM2-2164G variant genotypes and lung cancer risk. Our results suggest that the MDM2-2580G allele may be a marker of reduced genetic susceptibility to lung cancer in the non-Hispanic white population, a finding that seems to contradict previous reports.

Duke Scholars

Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

October 2006

Volume

27

Issue

10

Start / End Page

2028 / 2033

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
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Li, G., Zhai, X., Zhang, Z., Chamberlain, R. M., Spitz, M. R., & Wei, Q. (2006). MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis. Carcinogenesis, 27(10), 2028–2033. https://doi.org/10.1093/carcin/bgl047
Li, Guojun, Xiaodong Zhai, Zhengdong Zhang, Robert M. Chamberlain, Margaret R. Spitz, and Qingyi Wei. “MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.Carcinogenesis 27, no. 10 (October 2006): 2028–33. https://doi.org/10.1093/carcin/bgl047.
Li G, Zhai X, Zhang Z, Chamberlain RM, Spitz MR, Wei Q. MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis. Carcinogenesis. 2006 Oct;27(10):2028–33.
Li, Guojun, et al. “MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis.Carcinogenesis, vol. 27, no. 10, Oct. 2006, pp. 2028–33. Pubmed, doi:10.1093/carcin/bgl047.
Li G, Zhai X, Zhang Z, Chamberlain RM, Spitz MR, Wei Q. MDM2 gene promoter polymorphisms and risk of lung cancer: a case-control analysis. Carcinogenesis. 2006 Oct;27(10):2028–2033.
Journal cover image

Published In

Carcinogenesis

DOI

ISSN

0143-3334

Publication Date

October 2006

Volume

27

Issue

10

Start / End Page

2028 / 2033

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genetic Predisposition to Disease