Skip to main content
Journal cover image

Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.

Publication ,  Journal Article
Ma, H; Hu, Z; Zhai, X; Wang, S; Wang, X; Qin, J; Jin, G; Liu, J; Wang, X; Wei, Q; Shen, H
Published in: Cancer Lett
August 28, 2006

MDM2 is a phosphoprotein that interacts with P53 and inhibits its activity. Recently, a T/G substitution (SNP309) in the promoter of MDM2 was identified and has been demonstrated to be associated with an increased MDM2 expression and a significantly earlier age of onset of several tumors, including breast cancer. To test the hypothesis that this functional variant in the MDM2 promoter is associated with risk of breast cancer, we conducted a molecular epidemiological study of 366 breast cancer cases (BC), 263 patients with benign breast diseases (BBD) and 605 cancer-free controls in China, in which we genotyped this T/G variant and another common insertion/deletion polymorphism (Del1518) in the MDM2 promoter and evaluated the associations between these two polymorphisms and breast cancer risk. We found that the variant allele frequencies of these two polymorphisms were not statistically different between the cases and controls (SNP309G: 0.500, 0.542, and 0.506 in BC, BBD, and controls, respectively, and Del1518-: 0.296, 0.308, and 0.297 in BC, BBD, and controls, respectively). Logistic regression analyses revealed that the variant genotypes of both MDM2 SNP309 and Del1518 polymorphisms were not significantly associated with risk of breast cancer (adjusted OR, 1.03; 95% CI, 0.74-1.42 for SNP309 TG and GG; and adjusted OR, 1.09; 95% CI, 0.83-1.43 for Del1518 +/- and -/-). These findings suggest that these two MDM2 promoter variants may not play a major role in the etiology of breast cancer.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

August 28, 2006

Volume

240

Issue

2

Start / End Page

261 / 267

Location

Ireland

Related Subject Headings

  • Sequence Deletion
  • Risk Factors
  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ma, H., Hu, Z., Zhai, X., Wang, S., Wang, X., Qin, J., … Shen, H. (2006). Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population. Cancer Lett, 240(2), 261–267. https://doi.org/10.1016/j.canlet.2005.09.019
Ma, Hongxia, Zhibin Hu, Xiangjun Zhai, Shui Wang, Xuechen Wang, Jianwei Qin, Guangfu Jin, et al. “Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.Cancer Lett 240, no. 2 (August 28, 2006): 261–67. https://doi.org/10.1016/j.canlet.2005.09.019.
Ma H, Hu Z, Zhai X, Wang S, Wang X, Qin J, et al. Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population. Cancer Lett. 2006 Aug 28;240(2):261–7.
Ma, Hongxia, et al. “Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population.Cancer Lett, vol. 240, no. 2, Aug. 2006, pp. 261–67. Pubmed, doi:10.1016/j.canlet.2005.09.019.
Ma H, Hu Z, Zhai X, Wang S, Wang X, Qin J, Jin G, Liu J, Wei Q, Shen H. Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population. Cancer Lett. 2006 Aug 28;240(2):261–267.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

August 28, 2006

Volume

240

Issue

2

Start / End Page

261 / 267

Location

Ireland

Related Subject Headings

  • Sequence Deletion
  • Risk Factors
  • Proto-Oncogene Proteins c-mdm2
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Genotype
  • Genetic Predisposition to Disease