The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.

Published

Journal Article

Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.

Full Text

Duke Authors

Cited Authors

  • McDonald, JM; Dunlap, S; Cogdell, D; Dunmire, V; Wei, Q; Starzinski-Powitz, A; Sawaya, R; Bruner, J; Fuller, GN; Aldape, K; Zhang, W

Published Date

  • March 9, 2006

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 300 - 304

PubMed ID

  • 16410724

Pubmed Central ID

  • 16410724

Electronic International Standard Serial Number (EISSN)

  • 1555-8576

International Standard Serial Number (ISSN)

  • 1538-4047

Digital Object Identifier (DOI)

  • 10.4161/cbt.5.3.2391

Language

  • eng