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Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.

Publication ,  Journal Article
Yang, J; Hu, Z; Xu, Y; Shen, J; Niu, J; Hu, X; Guo, J; Wei, Q; Wang, X; Shen, H
Published in: Cancer Lett
November 25, 2004

Studies suggest that IL-1beta (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C-31T and T-511C) in the IL-1B promoter were suggested to be correlated with alteration of Helicobacter pylori infection and IL-1beta expression and therefore may be associated with risk of gastric cancer. To test the hypothesis that these two polymorphisms are associated with gastric cancer risk, we performed a case-control study of 280 histologically confirmed gastric cancer patients and 258 age, sex frequency-matched cancer-free controls in a Chinese population. Multivariate logistic regression analyses revealed that the risks (adjusted odds ratio [OR] and 95% confidence interval [CI]) associated with the IL-1B variant genotypes were 1.64 (95% CI, 1.01-2.66) for -31TT and 1.52 (95% CI, 0.91-2.54) for -511CC, respectively, compared with their wild-type homozygotes. The risks were significantly more evident in individuals with H. pylori infection (adjusted OR, 2.14; 95% CI, 1.13-4.06 for -31TT; adjusted OR, 2.00; 95% CI, 1.02-3.89 for -511CC), which was consistent with the biological effects of IL-1beta. When we used the haplotype analyses and assumed the IL-1B -31T and -511C as risk alleles, no synergistic effect was found between these two loci. These findings indicate that these two IL-1B promoter variants may contribute to the risk of developing gastric cancer in the Chinese population, especially in individuals with H. pylori infection.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

November 25, 2004

Volume

215

Issue

2

Start / End Page

191 / 198

Location

Ireland

Related Subject Headings

  • Stomach Neoplasms
  • Risk
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Peptide Fragments
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Interleukin-1beta
  • Interleukin-1
 

Citation

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Yang, J., Hu, Z., Xu, Y., Shen, J., Niu, J., Hu, X., … Shen, H. (2004). Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett, 215(2), 191–198. https://doi.org/10.1016/j.canlet.2004.07.012
Yang, Jie, Zhibin Hu, Yaochu Xu, Jin Shen, Juyin Niu, Xu Hu, Jiantao Guo, Qingyi Wei, Xinru Wang, and Hongbing Shen. “Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.Cancer Lett 215, no. 2 (November 25, 2004): 191–98. https://doi.org/10.1016/j.canlet.2004.07.012.
Yang J, Hu Z, Xu Y, Shen J, Niu J, Hu X, et al. Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett. 2004 Nov 25;215(2):191–8.
Yang, Jie, et al. “Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.Cancer Lett, vol. 215, no. 2, Nov. 2004, pp. 191–98. Pubmed, doi:10.1016/j.canlet.2004.07.012.
Yang J, Hu Z, Xu Y, Shen J, Niu J, Hu X, Guo J, Wei Q, Wang X, Shen H. Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett. 2004 Nov 25;215(2):191–198.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

November 25, 2004

Volume

215

Issue

2

Start / End Page

191 / 198

Location

Ireland

Related Subject Headings

  • Stomach Neoplasms
  • Risk
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Peptide Fragments
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Interleukin-1beta
  • Interleukin-1