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Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.

Publication ,  Journal Article
Wang, L; Soria, J-C; Chang, Y-S; Lee, H-Y; Wei, Q; Mao, L
Published in: Oncogene
October 16, 2003

Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown to play an important role in one's risk of developing lung cancer. We report here the identification of a polymorphic tandem repeats minisatellite (termed MNS16A) in the downstream region of the human telomerase gene. This minisatellite is located upstream of an antisense transcript from the human telomerase gene locus and was demonstrated to have promoter activity. The promoter activity was significantly lower in the construct containing the shorter repeats, suggesting that the MNS16A variant may have a relevance of functionality. To explore the role of this novel polymorphism in lung cancer, we conducted a pilot hospital-based case-control study by identifying the MNS16A genotype with genomic DNA from 53 lung cancer patients and 72 cancer-free controls. We found four different alleles and classified them as shorter (S) or longer (L) on the functional basis of the length of the repeats in the controls. The MNS16A genotype distributions of the SS, SL, and LL genotypes were 11, 32, and 57%, respectively, in the cases, and 14, 40, and 46%, respectively, in the controls. Compared with the SS+SL genotype, the LL genotype was associated with greater than twofold increased risk of lung cancer (odds ratio=2.18; 95% confidence interval=0.92, 5.20) after adjustment for age, sex, ethnicity, and smoking status, suggesting a potential role of MNS16A in lung cancer susceptibility. Larger studies are needed to verify our findings.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 16, 2003

Volume

22

Issue

46

Start / End Page

7123 / 7129

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Transcription, Genetic
  • Telomerase
  • Tandem Repeat Sequences
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA Probes
  • Promoter Regions, Genetic
  • Plasmids
  • Oncology & Carcinogenesis
 

Citation

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Wang, L., Soria, J.-C., Chang, Y.-S., Lee, H.-Y., Wei, Q., & Mao, L. (2003). Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. Oncogene, 22(46), 7123–7129. https://doi.org/10.1038/sj.onc.1206852
Wang, Luo, Jean-Charles Soria, Yoon-Soo Chang, Ho-Young Lee, Qingyi Wei, and Li Mao. “Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.Oncogene 22, no. 46 (October 16, 2003): 7123–29. https://doi.org/10.1038/sj.onc.1206852.
Wang L, Soria J-C, Chang Y-S, Lee H-Y, Wei Q, Mao L. Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. Oncogene. 2003 Oct 16;22(46):7123–9.
Wang, Luo, et al. “Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.Oncogene, vol. 22, no. 46, Oct. 2003, pp. 7123–29. Pubmed, doi:10.1038/sj.onc.1206852.
Wang L, Soria J-C, Chang Y-S, Lee H-Y, Wei Q, Mao L. Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. Oncogene. 2003 Oct 16;22(46):7123–7129.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 16, 2003

Volume

22

Issue

46

Start / End Page

7123 / 7129

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transfection
  • Transcription, Genetic
  • Telomerase
  • Tandem Repeat Sequences
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA Probes
  • Promoter Regions, Genetic
  • Plasmids
  • Oncology & Carcinogenesis