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An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study.

Publication ,  Journal Article
Shen, H; Sturgis, EM; Khan, SG; Qiao, Y; Shahlavi, T; Eicher, SA; Xu, Y; Wang, X; Strom, SS; Spitz, MR; Kraemer, KH; Wei, Q
Published in: Cancer Res
April 15, 2001

Inherited polymorphisms of DNA repair genes may contribute to variations in DNA repair capacity and genetic susceptibility to cancer. In a hospital-based case-control study of 287 non-Hispanic white patients with newly diagnosed SCCHN and 311 control subjects matched on age, sex, ethnicity, and smoking status, we investigated the role of a newly identified variant allele of XPC, XPC-PAT+. We found that the frequency of the XPC-PAT+ allele was higher in the cases (0.409) than in the controls (0.333; P = 0.007). Fifty cases (17.4%) and 37 controls (11.9%) were XPC-PAT+/+, and 135 (47.0%) cases and 133 controls (42.8%) were XPC-PAT+/-. XPC-PAT+/- and XPC-PAT+/+ subjects were at significantly increased risk for SCCHN [adjusted odds ratios = 1.44 and 1.85, respectively (95% confidence intervals, 1.01-2.05 and 1.12-3.05, respectively; trend test, P = 0.007)]. We did not find ethnic difference in the frequency of XPC-PAT+ allele among four groups aged between 19 and 75 years: non-Hispanic whites, 294; African-Americans, 178; Hispanic-Americans, 103; and native Chinese, 119 (0.333, 0.281, 0.296, and 0.353, respectively). The case-control findings support the hypothesis that the XPC-PAT+ allele may contribute to the risk of developing SCCHN.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

April 15, 2001

Volume

61

Issue

8

Start / End Page

3321 / 3325

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Poly T
  • Poly A
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Introns
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shen, H., Sturgis, E. M., Khan, S. G., Qiao, Y., Shahlavi, T., Eicher, S. A., … Wei, Q. (2001). An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Res, 61(8), 3321–3325.
Shen, H., E. M. Sturgis, S. G. Khan, Y. Qiao, T. Shahlavi, S. A. Eicher, Y. Xu, et al. “An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study.Cancer Res 61, no. 8 (April 15, 2001): 3321–25.
Shen H, Sturgis EM, Khan SG, Qiao Y, Shahlavi T, Eicher SA, et al. An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Res. 2001 Apr 15;61(8):3321–5.
Shen H, Sturgis EM, Khan SG, Qiao Y, Shahlavi T, Eicher SA, Xu Y, Wang X, Strom SS, Spitz MR, Kraemer KH, Wei Q. An intronic poly (AT) polymorphism of the DNA repair gene XPC and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Res. 2001 Apr 15;61(8):3321–3325.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

April 15, 2001

Volume

61

Issue

8

Start / End Page

3321 / 3325

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Poly T
  • Poly A
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Introns
  • Humans