Skip to main content

Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines.

Publication ,  Journal Article
Zou, C; Wang, L; Liebert, M; Grossman, HB; Lotan, R; Wei, Q
Published in: Int J Oncol
November 1998

The incidence of bladder cancer has increased in the United States during the past 50 years, consistent with increased exposure to bladder carcinogens in the environment and tobacco use. Although N-(4-hydroxyphenyl) retinamide (4-HPR), a retinoid derivative, has been used as a chemopreventive agent of bladder cancer in clinical trials, little is known about its mechanisms of action against bladder cancer cells. Previous studies suggest this chemopreventive agent may inhibit tumor growth by inducing apoptosis. To further investigate this putative effect, we examined the effect of 4-HPR and gamma-radiation and their combined effects in three selected bladder cancer cell lines. Indeed, 4-HPR induced apoptosis in these cell lines in a dose-dependent manner. A 2.5 microM dose of 4-HPR and 50 rad of gamma-irradiation induced about 10% increase in apoptotic cells, respectively. However, this low dose 4-HPR combined with low dose gamma-irradiation had a synergistic effect on apoptosis, in which apoptotic cells increased by more than 30%. The findings have potential clinical implications and warrant further investigations both in vitro and in vivo in bladder cancer.

Duke Scholars

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

November 1998

Volume

13

Issue

5

Start / End Page

1037 / 1041

Location

Greece

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Humans
  • Gamma Rays
  • Fenretinide
  • Combined Modality Therapy
  • Chromosome Aberrations
  • Chromatids
  • Chemoprevention
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zou, C., Wang, L., Liebert, M., Grossman, H. B., Lotan, R., & Wei, Q. (1998). Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines. Int J Oncol, 13(5), 1037–1041. https://doi.org/10.3892/ijo.13.5.1037
Zou, C., L. Wang, M. Liebert, H. B. Grossman, R. Lotan, and Q. Wei. “Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines.Int J Oncol 13, no. 5 (November 1998): 1037–41. https://doi.org/10.3892/ijo.13.5.1037.
Zou C, Wang L, Liebert M, Grossman HB, Lotan R, Wei Q. Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines. Int J Oncol. 1998 Nov;13(5):1037–41.
Zou, C., et al. “Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines.Int J Oncol, vol. 13, no. 5, Nov. 1998, pp. 1037–41. Pubmed, doi:10.3892/ijo.13.5.1037.
Zou C, Wang L, Liebert M, Grossman HB, Lotan R, Wei Q. Combined effect of chemopreventive agent N-(4-hydroxyphenyl) retinamide (4-HPR) and gamma-radiation on bladder cancer cell lines. Int J Oncol. 1998 Nov;13(5):1037–1041.

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

November 1998

Volume

13

Issue

5

Start / End Page

1037 / 1041

Location

Greece

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Humans
  • Gamma Rays
  • Fenretinide
  • Combined Modality Therapy
  • Chromosome Aberrations
  • Chromatids
  • Chemoprevention