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Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.

Publication ,  Journal Article
Soliman, AS; Bondy, ML; Guan, Y; El-Badawi, S; Mokhtar, N; Bayomi, S; Raouf, AA; Ismail, S; McPherson, RS; Abdel-Hakim, TF; Beasley, RP ...
Published in: Int J Oncol
June 1998

An Egyptian hospital-based pilot case-control study was conducted to investigate the relationship between the expression level of mismatch repair (MMR) genes and the risk of colorectal cancer. The relative expression of five known MMR genes, i.e., hMSH2, hMLH1, hPMS1, hPMS2, and GTBP/hMSH6, was measured by a multiplex reverse transcriptase (RT)-polymerase chain reaction (PCR) in peripheral blood lymphocytes from 31 colorectal cancer patients and 47 age- and-sex matched controls. The expression of hMSH2, GTBP/hMSH6, hPMS1 and hPMS2 tended to be lower in patients than controls, but only the difference in hPMS2 expression was statistically significant (p<0. 01). Although 50% of the cases had chemotherapy or radiotherapy within the last six months before the blood was drawn, their gene expression was not statistically different from those who had not undergone such therapies. After adjustment for age and sex, the odds ratios (OR) calculated from a logistical regression model, using the median levels of gene expression of controls as cut-off values, indicated that increased risk was associated with reduced expressions of both hPMS1 (OR = 3.97, 95% confidence interval (CI) = 1.04 to 7.65) and hPMS2 (OR = 2.86, 95% CI = 1.05 to 7.76). Although the results of this study were inconclusive because of the small sample size and use of prevalent cases, it is biologically plausible that patients with colorectal cancers may have a lower expression of MMR genes than healthy controls because malfunction of these genes has been shown in hereditary nonpolyposis colon cancer. The involvement of low hPMS2 expression in colon cancer risk seems to be unique in the Egyptian population. Further studies with newly diagnosed patients before they begin therapy will provide more convincing data about the role of MMR gene expression in the etiology of colorectal cancers in Egypt.

Duke Scholars

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

June 1998

Volume

12

Issue

6

Start / End Page

1315 / 1319

Location

Greece

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Proto-Oncogene Proteins
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Proteins
  • MutS Homolog 2 Protein
  • MutL Proteins
  • MutL Protein Homolog 1
  • Mismatch Repair Endonuclease PMS2
 

Citation

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Soliman, A. S., Bondy, M. L., Guan, Y., El-Badawi, S., Mokhtar, N., Bayomi, S., … Wei, Q. (1998). Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. Int J Oncol, 12(6), 1315–1319. https://doi.org/10.3892/ijo.12.6.1315
Soliman, A. S., M. L. Bondy, Y. Guan, S. El-Badawi, N. Mokhtar, S. Bayomi, A. A. Raouf, et al. “Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.Int J Oncol 12, no. 6 (June 1998): 1315–19. https://doi.org/10.3892/ijo.12.6.1315.
Soliman AS, Bondy ML, Guan Y, El-Badawi S, Mokhtar N, Bayomi S, et al. Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. Int J Oncol. 1998 Jun;12(6):1315–9.
Soliman, A. S., et al. “Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.Int J Oncol, vol. 12, no. 6, June 1998, pp. 1315–19. Pubmed, doi:10.3892/ijo.12.6.1315.
Soliman AS, Bondy ML, Guan Y, El-Badawi S, Mokhtar N, Bayomi S, Raouf AA, Ismail S, McPherson RS, Abdel-Hakim TF, Beasley RP, Levin B, Wei Q. Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. Int J Oncol. 1998 Jun;12(6):1315–1319.

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

June 1998

Volume

12

Issue

6

Start / End Page

1315 / 1319

Location

Greece

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Proto-Oncogene Proteins
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Proteins
  • MutS Homolog 2 Protein
  • MutL Proteins
  • MutL Protein Homolog 1
  • Mismatch Repair Endonuclease PMS2