Mutagen sensitivity and risk of gliomas: a case-control analysis.

Journal Article (Journal Article)

Although the risk factors contributing to the etiology of brain tumors remain largely unknown, this pilot study suggests that genetically determined sensitivity to environmental carcinogens may play a role in the pathogenesis of these tumors. In this study, we examined short-term lymphocyte cultures from 45 adult malignant glioma patients and 117 age-, sex-, and ethnicity-matched healthy controls for mutagen-induced chromatid breaks and evaluated their family history of cancer, smoking, and demographic variables to ascertain the association between mutagen sensitivity and risk of brain tumors. The mutagen selected was gamma-radiation. The mean number of induced breaks/cell was 0.72 (SD=0.45) for the cases and 0.45 (SD = 0.35) for the controls (P < 0.0001). Using the median number of induced breaks/cell in the controls as the breakpoint for defining mutagen sensitivity, we observed an unadjusted odds ratio of 5.36 (95% confidence interval = 2.12-13.69) for mutagen sensitivity and brain tumor risk and an adjusted odds ratio of 5.79 (2.26-14.83), when we controlled for epidemiological risk factors including smoking, race, income, and education. Although a larger study is needed to confirm this intriguing result, these preliminary findings suggest that increased sensitivity to radiation is an independent risk factor for gliomas.

Full Text

Duke Authors

Cited Authors

  • Bondy, ML; Kyritsis, AP; Gu, J; de Andrade, M; Cunningham, J; Levin, VA; Bruner, JM; Wei, Q

Published Date

  • April 1, 1996

Published In

Volume / Issue

  • 56 / 7

Start / End Page

  • 1484 - 1486

PubMed ID

  • 8603389

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng

Conference Location

  • United States