Profound reduction of invariant natural killer T cells in the peripheral blood of a patient with interleukin-1 receptor-associated kinase 4 deficiency.

Journal Article (Letter)

We previously described a patient with a history of frequent life-threatening pneumonias, infections with bacterial pathogens, interleukin 1 receptor-associated kinase 4 deficiency, and failure to maintain antibody titers to polysaccharide antigens or to a neoantigen bacteriophage. In the present study, we show that the patient's peripheral blood mononuclear cells have a profound deficiency of invariant natural killer T cells.

Full Text

Duke Authors

Cited Authors

  • Haraguchi, S; Day, NK; Tangsinmankong, N; Sleasman, JW

Published Date

  • August 16, 2010

Published In

Volume / Issue

  • 132 / 1-2

Start / End Page

  • 86 - 89

PubMed ID

  • 20441778

Electronic International Standard Serial Number (EISSN)

  • 1879-0542

Digital Object Identifier (DOI)

  • 10.1016/j.imlet.2010.04.011


  • eng

Conference Location

  • Netherlands