Nucleoside-analogue reverse-transcriptase inhibitors plus nevirapine, nelfinavir, or ritonavir for pretreated children infected with human immunodeficiency virus type 1.


Journal Article

The relative potency and tolerability of multidrug regimens used to treat infants and children infected with human immunodeficiency virus type 1 (HIV-1) are largely unknown. In Pediatric AIDS Clinical Trials Group (PACTG) Protocol 377, 181 infants and children were assigned to receive stavudine (d4T) plus nevirapine (NVP) and ritonavir (RTV); d4T plus lamivudine (3TC) and nelfinavir (NFV); d4T plus NVP and NFV; or d4T plus 3TC, NVP, and NFV. Eleven additional children received d4T and NVP plus NFV given twice daily. All subjects had not previously received protease inhibitors or nonnucleoside reverse-transcriptase inhibitors and all had been immunologically stable while receiving reverse-transcriptase inhibitor therapy. After 48 weeks of therapy, 17 (41%) of 41 subjects receiving d4T-NVP-RTV, 13 (30%) of 44 receiving d4T-NVP-NFV, 21 (42%) of 50 receiving d4T-3TC and NFV (3 times daily), and 22 (52%) of 42 receiving d4T-3TC-NVP-NFV were still receiving their assigned therapy and had HIV-1 RNA suppression to

Full Text

Duke Authors

Cited Authors

  • Krogstad, P; Lee, S; Johnson, G; Stanley, K; McNamara, J; Moye, J; Jackson, JB; Aguayo, R; Dieudonne, A; Khoury, M; Mendez, H; Nachman, S; Wiznia, A; Pediatric AIDS Clinical Trials Group 377 Study Team,

Published Date

  • April 1, 2002

Published In

Volume / Issue

  • 34 / 7

Start / End Page

  • 991 - 1001

PubMed ID

  • 11880966

Pubmed Central ID

  • 11880966

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/338814


  • eng

Conference Location

  • United States