Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.
(Clinical Trial;Journal Article)
OBJECTIVE: The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of neonatal herpes simplex virus (HSV) disease. In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed. PARTICIPANTS: Infants who were
Kimberlin, DW; Lin, CY; Jacobs, RF; Powell, DA; Corey, L; Gruber, WC; Rathore, M; Bradley, JS; Diaz, PS; Kumar, M; Arvin, AM; Gutierrez, K; Shelton, M; Weiner, LB; Sleasman, JW; de Sierra, TM; Weller, S; Soong, SJ; Kiell, J; Lakeman, FD; Whitley, RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group,
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