Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.

Journal Article (Clinical Trial;Journal Article)

OBJECTIVE: The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of neonatal herpes simplex virus (HSV) disease. In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed. PARTICIPANTS: Infants who were

Full Text

Duke Authors

Cited Authors

  • Kimberlin, DW; Lin, CY; Jacobs, RF; Powell, DA; Corey, L; Gruber, WC; Rathore, M; Bradley, JS; Diaz, PS; Kumar, M; Arvin, AM; Gutierrez, K; Shelton, M; Weiner, LB; Sleasman, JW; de Sierra, TM; Weller, S; Soong, SJ; Kiell, J; Lakeman, FD; Whitley, RJ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group,

Published Date

  • August 2001

Published In

Volume / Issue

  • 108 / 2

Start / End Page

  • 230 - 238

PubMed ID

  • 11483782

Electronic International Standard Serial Number (EISSN)

  • 1098-4275

Digital Object Identifier (DOI)

  • 10.1542/peds.108.2.230


  • eng

Conference Location

  • United States