Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.

Published

Journal Article

The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.

Full Text

Duke Authors

Cited Authors

  • Lamers, SL; Sleasman, JW; She, JX; Barrie, KA; Pomeroy, SM; Barrett, DJ; Goodenow, MM

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 93 / 1

Start / End Page

  • 380 - 390

PubMed ID

  • 8282808

Pubmed Central ID

  • 8282808

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI116970

Language

  • eng

Conference Location

  • United States