Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission.
Journal Article (Journal Article)
The extent of nucleotide variation within the HIV-1 env hypervariable domains serves as a marker of virus genotypes within infected individuals and as a means to track transmission of the virus between individuals. We analyzed env V1 and V2 sequences in longitudinal samples from two HIV-1-infected mothers, each with three children infected by maternal transmission of the virus. Sequences in samples that were obtained from two infants at 2 d and 4 wk after birth displayed more variation in V1 and V2 than maternal samples obtained at the same times. Multiple HIV-1 genotypes were identified in each mother. In each family, multiple maternal HIV-1 genotypes were transmitted to the infants. Specific amino acid residues in the hypervariable domains were conserved within sequences from each family producing a family-specific amino acid signature pattern in V1 and V2. Viruses that were highly related to maternal viruses in signature pattern persisted for as long as 4 yr in the older children. Results support a model of transmission involving multiple HIV-1 genotypes with development of genetic variation from differential outgrowth and accumulation of genetic changes within each individual.
Full Text
Duke Authors
Cited Authors
- Lamers, SL; Sleasman, JW; She, JX; Barrie, KA; Pomeroy, SM; Barrett, DJ; Goodenow, MM
Published Date
- January 1994
Published In
Volume / Issue
- 93 / 1
Start / End Page
- 380 - 390
PubMed ID
- 8282808
Pubmed Central ID
- PMC293789
International Standard Serial Number (ISSN)
- 0021-9738
Digital Object Identifier (DOI)
- 10.1172/JCI116970
Language
- eng
Conference Location
- United States