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High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.

Publication ,  Journal Article
Shah, SJ; Marcus, GM; Gerber, IL; McKeown, BH; Vessey, JC; Jordan, MV; Huddleston, M; Foster, E; Chatterjee, K; Michaels, AD
Published in: J Card Fail
February 2006

BACKGROUND: Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP. METHODS AND RESULTS: In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus (P =.006) and heart failure (P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated (P =.046). CONCLUSION: CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

February 2006

Volume

12

Issue

1

Start / End Page

61 / 65

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Prospective Studies
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Heart Ventricles
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shah, S. J., Marcus, G. M., Gerber, I. L., McKeown, B. H., Vessey, J. C., Jordan, M. V., … Michaels, A. D. (2006). High-sensitivity C-reactive protein and parameters of left ventricular dysfunction. J Card Fail, 12(1), 61–65. https://doi.org/10.1016/j.cardfail.2005.08.003
Shah, Sanjiv J., Gregory M. Marcus, Ivor L. Gerber, Barry H. McKeown, Joshua C. Vessey, Mark V. Jordan, Michele Huddleston, Elyse Foster, Kanu Chatterjee, and Andrew D. Michaels. “High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.J Card Fail 12, no. 1 (February 2006): 61–65. https://doi.org/10.1016/j.cardfail.2005.08.003.
Shah SJ, Marcus GM, Gerber IL, McKeown BH, Vessey JC, Jordan MV, et al. High-sensitivity C-reactive protein and parameters of left ventricular dysfunction. J Card Fail. 2006 Feb;12(1):61–5.
Shah, Sanjiv J., et al. “High-sensitivity C-reactive protein and parameters of left ventricular dysfunction.J Card Fail, vol. 12, no. 1, Feb. 2006, pp. 61–65. Pubmed, doi:10.1016/j.cardfail.2005.08.003.
Shah SJ, Marcus GM, Gerber IL, McKeown BH, Vessey JC, Jordan MV, Huddleston M, Foster E, Chatterjee K, Michaels AD. High-sensitivity C-reactive protein and parameters of left ventricular dysfunction. J Card Fail. 2006 Feb;12(1):61–65.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

February 2006

Volume

12

Issue

1

Start / End Page

61 / 65

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Dysfunction, Left
  • Stroke Volume
  • Prospective Studies
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Heart Ventricles
  • Female