Obese patients have lower B-type and atrial natriuretic peptide levels compared with nonobese.


Journal Article

Obesity is a risk factor for the development of heart failure, but the causal mechanism remains unclear. Impaired production or enhanced clearance of natriuretic peptides, which regulate sodium balance and sympathetic activation, may play an important role. The authors investigated the relationship of plasma B-type natriuretic peptide and atrial natriuretic peptide levels to body mass index in 100 patients referred for left heart catheterization. Hemodynamic and echocardiographic data were obtained for all study participants. Atrial natriuretic peptide and B-type natriuretic peptide levels were compared in obese (body mass index > or = 30 kg/m2) and nonobese (body mass index < 30 kg/m2) subjects. Multivariate regression analyses were performed, adjusting for clinical and hemodynamic covariates. Obese patients had significantly lower B-type natriuretic peptide (p = 0.03) and atrial natriuretic peptide (p = 0.04) levels compared with nonobese. Multivariate analysis revealed lower B-type natriuretic peptide (p = 0.095) and atrial natriuretic peptide (p = 0.007) levels in obese patients while controlling for age, sex, left ventricular end-diastolic pressure, and left ventricular ejection fraction. Low levels of circulating natriuretic peptides are thus associated with obesity and may contribute to the development of heart failure.

Full Text

Duke Authors

Cited Authors

  • Khush, KK; Gerber, IL; McKeown, B; Marcus, G; Vessey, J; Foster, E; Chatterjee, K; Michaels, AD

Published Date

  • March 2006

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 85 - 90

PubMed ID

  • 16596042

Pubmed Central ID

  • 16596042

International Standard Serial Number (ISSN)

  • 1527-5299

Digital Object Identifier (DOI)

  • 10.1111/j.1527-5299.2006.04900.x


  • eng

Conference Location

  • United States