An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.

Journal Article (Journal Article)

Previous research indicates that drug motivational systems are instantiated in structures that process information related to incentive, motivational drive, memorial, motor/habit, craving, and cognitive control processing. The present research tests the hypothesis that activity in such systems will be powerfully affected by the combination of drug anticipation and drug withdrawal. Event-related fMRI was used to examine activation in response to a preinfusion warning cue in two experimental sessions that manipulated withdrawal status. Significant cue-induced effects were seen in the caudate, ventral anterior nucleus of the thalamus, the insula, subcallosal gyrus, nucleus accumbens, and anterior cingulate. These results suggest that withdrawal and nicotine anticipation produce (1) different motor preparatory and inhibitory response processing and (2) different craving related processing.

Full Text

Duke Authors

Cited Authors

  • Gloria, R; Angelos, L; Schaefer, HS; Davis, JM; Majeskie, M; Richmond, BS; Curtin, JJ; Davidson, RJ; Baker, TB

Published Date

  • July 2009

Published In

Volume / Issue

  • 46 / 4

Start / End Page

  • 681 - 693

PubMed ID

  • 19490513

Pubmed Central ID

  • PMC2706918

Electronic International Standard Serial Number (EISSN)

  • 1540-5958

Digital Object Identifier (DOI)

  • 10.1111/j.1469-8986.2009.00823.x


  • eng

Conference Location

  • United States