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An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.

Publication ,  Journal Article
Gloria, R; Angelos, L; Schaefer, HS; Davis, JM; Majeskie, M; Richmond, BS; Curtin, JJ; Davidson, RJ; Baker, TB
Published in: Psychophysiology
July 2009

Previous research indicates that drug motivational systems are instantiated in structures that process information related to incentive, motivational drive, memorial, motor/habit, craving, and cognitive control processing. The present research tests the hypothesis that activity in such systems will be powerfully affected by the combination of drug anticipation and drug withdrawal. Event-related fMRI was used to examine activation in response to a preinfusion warning cue in two experimental sessions that manipulated withdrawal status. Significant cue-induced effects were seen in the caudate, ventral anterior nucleus of the thalamus, the insula, subcallosal gyrus, nucleus accumbens, and anterior cingulate. These results suggest that withdrawal and nicotine anticipation produce (1) different motor preparatory and inhibitory response processing and (2) different craving related processing.

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Published In

Psychophysiology

DOI

EISSN

1469-8986

Publication Date

July 2009

Volume

46

Issue

4

Start / End Page

681 / 693

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Experimental Psychology
  • Cues
  • Carbon Monoxide
 

Citation

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Gloria, R., Angelos, L., Schaefer, H. S., Davis, J. M., Majeskie, M., Richmond, B. S., … Baker, T. B. (2009). An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation. Psychophysiology, 46(4), 681–693. https://doi.org/10.1111/j.1469-8986.2009.00823.x
Gloria, Rebecca, Lisa Angelos, Hillary S. Schaefer, James M. Davis, Matthew Majeskie, Burke S. Richmond, John J. Curtin, Richard J. Davidson, and Timothy B. Baker. “An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.Psychophysiology 46, no. 4 (July 2009): 681–93. https://doi.org/10.1111/j.1469-8986.2009.00823.x.
Gloria R, Angelos L, Schaefer HS, Davis JM, Majeskie M, Richmond BS, et al. An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation. Psychophysiology. 2009 Jul;46(4):681–93.
Gloria, Rebecca, et al. “An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation.Psychophysiology, vol. 46, no. 4, July 2009, pp. 681–93. Pubmed, doi:10.1111/j.1469-8986.2009.00823.x.
Gloria R, Angelos L, Schaefer HS, Davis JM, Majeskie M, Richmond BS, Curtin JJ, Davidson RJ, Baker TB. An fMRI investigation of the impact of withdrawal on regional brain activity during nicotine anticipation. Psychophysiology. 2009 Jul;46(4):681–693.
Journal cover image

Published In

Psychophysiology

DOI

EISSN

1469-8986

Publication Date

July 2009

Volume

46

Issue

4

Start / End Page

681 / 693

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Female
  • Experimental Psychology
  • Cues
  • Carbon Monoxide