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Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.

Publication ,  Journal Article
Luu, HH; Zhou, L; Haydon, RC; Deyrup, AT; Montag, AG; Huo, D; Heck, R; Heizmann, CW; Peabody, TD; Simon, MA; He, T-C
Published in: Cancer Lett
November 8, 2005

While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

Duke Scholars

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

November 8, 2005

Volume

229

Issue

1

Start / End Page

135 / 148

Location

Ireland

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Analysis
  • S100 Proteins
  • S100 Calcium Binding Protein A6
  • Phenotype
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Male
  • Immunohistochemistry
 

Citation

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Luu, H. H., Zhou, L., Haydon, R. C., Deyrup, A. T., Montag, A. G., Huo, D., … He, T.-C. (2005). Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. Cancer Lett, 229(1), 135–148. https://doi.org/10.1016/j.canlet.2005.02.015
Luu, Hue H., Lan Zhou, Rex C. Haydon, Andrea T. Deyrup, Anthony G. Montag, Dezheng Huo, Robert Heck, et al. “Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.Cancer Lett 229, no. 1 (November 8, 2005): 135–48. https://doi.org/10.1016/j.canlet.2005.02.015.
Luu, Hue H., et al. “Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.Cancer Lett, vol. 229, no. 1, Nov. 2005, pp. 135–48. Pubmed, doi:10.1016/j.canlet.2005.02.015.
Luu HH, Zhou L, Haydon RC, Deyrup AT, Montag AG, Huo D, Heck R, Heizmann CW, Peabody TD, Simon MA, He T-C. Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma. Cancer Lett. 2005 Nov 8;229(1):135–148.
Journal cover image

Published In

Cancer Lett

DOI

ISSN

0304-3835

Publication Date

November 8, 2005

Volume

229

Issue

1

Start / End Page

135 / 148

Location

Ireland

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Analysis
  • S100 Proteins
  • S100 Calcium Binding Protein A6
  • Phenotype
  • Osteosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Male
  • Immunohistochemistry