Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.

Published

Journal Article

While most osteosarcoma patients have metastatic or micrometastatic lesions, less than 15% of them have clinically detectable metastatic diseases at presentation. To identify potential markers that may predict osteosarcoma metastasis, we analyzed the expression of S100A6 in 50 osteosarcoma cases and found that 84% of the analyzed specimens stained positive for S100A6. There is a trend towards decreased clinically evident metastasis with increased S100A6 staining. Overexpression of S100A6 in osteosarcoma cells decreases cell motility and anchorage independent growth on collagen gels. Our findings provide evidence that, while S100A6 is commonly overexpressed in human osteosarcoma, loss of its expression correlates with a metastatic phenotype.

Full Text

Duke Authors

Cited Authors

  • Luu, HH; Zhou, L; Haydon, RC; Deyrup, AT; Montag, AG; Huo, D; Heck, R; Heizmann, CW; Peabody, TD; Simon, MA; He, T-C

Published Date

  • November 2005

Published In

Volume / Issue

  • 229 / 1

Start / End Page

  • 135 - 148

PubMed ID

  • 16157226

Pubmed Central ID

  • 16157226

Electronic International Standard Serial Number (EISSN)

  • 1872-7980

International Standard Serial Number (ISSN)

  • 0304-3835

Digital Object Identifier (DOI)

  • 10.1016/j.canlet.2005.02.015

Language

  • eng