Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis.

Journal Article (Review)

Inappropriate activation of transcription factors is a common event in cancer. These transcription factors contribute to a malignant phenotype by regulating genes involved in cellular proliferation, survival, differentiation, angiogenesis, and invasion. An important goal remains identifying the targets of oncogenic transcription factors that execute these changes. STAT proteins are among the best-studied of these transcription factors, and are involved in oncogenesis both in vivo and in vitro. They thus represent an ideal model for understanding how transcription factors cause cancer through coordinated changes in gene expression. Recent studies have employed microarray-based expression analysis to comprehensively identify STAT target genes. Analysis of these targets can provide insight into mechanisms of neoplastic transformation, and may shed light on new strategies for targeted therapy.

Full Text

Duke Authors

Cited Authors

  • Alvarez, JV; Frank, DA

Published Date

  • November 22, 2004

Published In

Volume / Issue

  • 3 / 11

Start / End Page

  • 1045 - 1050

PubMed ID

  • 15539936

Electronic International Standard Serial Number (EISSN)

  • 1555-8576

International Standard Serial Number (ISSN)

  • 1538-4047

Digital Object Identifier (DOI)

  • 10.4161/cbt.3.11.1172

Language

  • eng