Homer: a protein that selectively binds metabotropic glutamate receptors.

Published

Journal Article

Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors and ion channels. PDZ proteins are thought to have a role in defining the cellular distribution of the proteins that interact with them. Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. Homer is highly divergent from known PDZ proteins and seems to represent a novel family. The Homer gene is also distinct from members of the PDZ family in that its expression is regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development. This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling.

Full Text

Duke Authors

Cited Authors

  • Brakeman, PR; Lanahan, AA; O'Brien, R; Roche, K; Barnes, CA; Huganir, RL; Worley, PF

Published Date

  • March 20, 1997

Published In

Volume / Issue

  • 386 / 6622

Start / End Page

  • 284 - 288

PubMed ID

  • 9069287

Pubmed Central ID

  • 9069287

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/386284a0

Language

  • eng

Conference Location

  • England