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Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.

Publication ,  Journal Article
Assa'ad, AH; Putnam, PE; Collins, MH; Akers, RM; Jameson, SC; Kirby, CL; Buckmeier, BK; Bullock, JZ; Collier, AR; Konikoff, MR; Noel, RJ ...
Published in: J Allergy Clin Immunol
March 2007

BACKGROUND: Eosinophilic esophagitis (EE) is a gastrointestinal disorder that is increasingly diagnosed in pediatric patients. OBJECTIVE: We aimed to define, in pediatric patients with EE, their demographic and atopic characteristics, the histopathology of all segments of the gastrointestinal tract, and the effect of therapeutic interventions on the natural history. METHODS: We conducted a retrospective analysis of a database of pediatric patients with EE followed over a period of 8 years. RESULTS: In 89 pediatric patients with EE, male sex (78.6%), white race (94.4%), young age at diagnosis, mean +/- SD, 6.2 +/- 4.8 years, and atopy with sensitization to environmental and food allergens in 79% and 75%, respectively, were prevalent. Patients had EE of the proximal and distal esophagus, and 77% had in addition either mucosal eosinophilia or noneosinophilic histopathology in the stomach, duodenum, and colon. EE was chronic, with a duration of mean +/- SD, 0.91 +/- 0.84 years, until first resolution, and was recurrent; of 66% of the patients who had resolution, 79% later relapsed. CONCLUSION: Eosinophilic esophagitis in the pediatric population is a chronic and relapsing condition, associated with atopy and sometimes with subsequent histopathology in segments of the gastrointestinal tract other than the esophagus. CLINICAL IMPLICATIONS: Physicians evaluating pediatric patients with chronic gastrointestinal symptoms should consider the diagnosis of EE, particularly in young white male patients with atopy. Once diagnosed and treated, the physicians should follow the patients over a period of several years because the course of the disease is protracted, other gastrointestinal segments may be affected, and relapses are common.

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Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

March 2007

Volume

119

Issue

3

Start / End Page

731 / 738

Location

United States

Related Subject Headings

  • Stomach
  • Retrospective Studies
  • Male
  • Hypersensitivity, Immediate
  • Humans
  • Follow-Up Studies
  • Female
  • Esophagitis
  • Eosinophilia
  • Endoscopy
 

Citation

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ICMJE
MLA
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Assa’ad, A. H., Putnam, P. E., Collins, M. H., Akers, R. M., Jameson, S. C., Kirby, C. L., … Rothenberg, M. E. (2007). Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol, 119(3), 731–738. https://doi.org/10.1016/j.jaci.2006.10.044
Assa’ad, Amal H., Philip E. Putnam, Margaret H. Collins, Rachel M. Akers, Sean C. Jameson, Cassie L. Kirby, Bridget K. Buckmeier, et al. “Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.J Allergy Clin Immunol 119, no. 3 (March 2007): 731–38. https://doi.org/10.1016/j.jaci.2006.10.044.
Assa’ad AH, Putnam PE, Collins MH, Akers RM, Jameson SC, Kirby CL, et al. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007 Mar;119(3):731–8.
Assa’ad, Amal H., et al. “Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.J Allergy Clin Immunol, vol. 119, no. 3, Mar. 2007, pp. 731–38. Pubmed, doi:10.1016/j.jaci.2006.10.044.
Assa’ad AH, Putnam PE, Collins MH, Akers RM, Jameson SC, Kirby CL, Buckmeier BK, Bullock JZ, Collier AR, Konikoff MR, Noel RJ, Guajardo JR, Rothenberg ME. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol. 2007 Mar;119(3):731–738.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

March 2007

Volume

119

Issue

3

Start / End Page

731 / 738

Location

United States

Related Subject Headings

  • Stomach
  • Retrospective Studies
  • Male
  • Hypersensitivity, Immediate
  • Humans
  • Follow-Up Studies
  • Female
  • Esophagitis
  • Eosinophilia
  • Endoscopy