Skip to main content
Journal cover image

The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative.

Publication ,  Journal Article
Cannon, CM; Holthaus, CV; Zubrow, MT; Posa, P; Gunaga, S; Kella, V; Elkin, R; Davis, S; Turman, B; Weingarten, J; Milling, TJ; Lidsky, N ...
Published in: J Intensive Care Med
2013

BACKGROUND: Improved outcomes for severe sepsis and septic shock have been consistently observed with implementation of early best practice intervention strategies or the 6-hour resuscitation bundle (RB) in single-center studies. This multicenter study examines the in-hospital mortality effect of GENeralized Early Sepsis Intervention Strategies (GENESIS) when utilized in community and tertiary care settings. METHODS: This study was comprised of 2 strategies to assess treatment. The first was a prospective before-and-after observational comparison of historical controls to patients receiving the RB after implementation of GENESIS in 4 community and 4 tertiary hospitals. The second was a concurrent examination comparing patients not achieving all components of the RB to those achieving all components of the RB in 1 community and 2 tertiary care hospitals after implementation of GENESIS. These 4 subgroups merged to comprise a control (historical controls treated before GENESIS and RB not achieved after GENESIS) group and treatment (patients treated after GENESIS and RB achieved after GENESIS) group for comparison. RESULTS: The control group comprised 1554 patients not receiving the RB (952 before GENESIS and 602 RB not achieved after GENESIS). The treatment group comprised 4801 patients receiving the RB (4109 after GENESIS and 692 RB achieved after GENESIS). Patients receiving the RB (treatment group) experienced an in-hospital mortality reduction of 14% (42.8%-28.8%, P < .001) and a 5.1 day decrease in hospital length of stay (20.7 vs 15.6, P < .001) compared to those not receiving the RB (control group). Similar mortality reductions were seen in the before-and-after (43% vs 29%, P < .001) or concurrent RB not achieved versus achieved (42.5% vs 27.2%, P < .001) subgroup comparisons. CONCLUSIONS: Patients with severe sepsis and septic shock receiving the RB in community and tertiary hospitals experience similar and significant reductions in mortality and hospital length of stay. These findings remained consistent when examined in both before-and-after and concurrent analyses. Early sepsis intervention strategies are associated with 1 life being saved for every 7 treated.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Intensive Care Med

DOI

EISSN

1525-1489

Publication Date

2013

Volume

28

Issue

6

Start / End Page

355 / 368

Location

United States

Related Subject Headings

  • United States
  • Total Quality Management
  • Shock, Septic
  • Sepsis
  • Resuscitation
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cannon, C. M., Holthaus, C. V., Zubrow, M. T., Posa, P., Gunaga, S., Kella, V., … Rivers, E. P. (2013). The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. J Intensive Care Med, 28(6), 355–368. https://doi.org/10.1177/0885066612453025
Cannon, Chad M., Christopher V. Holthaus, Marc T. Zubrow, Pat Posa, Satheesh Gunaga, Vipul Kella, Ron Elkin, et al. “The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative.J Intensive Care Med 28, no. 6 (2013): 355–68. https://doi.org/10.1177/0885066612453025.
Cannon CM, Holthaus CV, Zubrow MT, Posa P, Gunaga S, Kella V, et al. The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. J Intensive Care Med. 2013;28(6):355–68.
Cannon, Chad M., et al. “The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative.J Intensive Care Med, vol. 28, no. 6, 2013, pp. 355–68. Pubmed, doi:10.1177/0885066612453025.
Cannon CM, Holthaus CV, Zubrow MT, Posa P, Gunaga S, Kella V, Elkin R, Davis S, Turman B, Weingarten J, Milling TJ, Lidsky N, Coba V, Suarez A, Yang JJ, Rivers EP. The GENESIS project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. J Intensive Care Med. 2013;28(6):355–368.
Journal cover image

Published In

J Intensive Care Med

DOI

EISSN

1525-1489

Publication Date

2013

Volume

28

Issue

6

Start / End Page

355 / 368

Location

United States

Related Subject Headings

  • United States
  • Total Quality Management
  • Shock, Septic
  • Sepsis
  • Resuscitation
  • Middle Aged
  • Male
  • Humans
  • Hospital Mortality
  • Female