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Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.

Publication ,  Journal Article
Reed, AM; Peterson, E; Bilgic, H; Ytterberg, SR; Amin, S; Hein, MS; Crowson, CS; Ernste, F; Gillespie, EB
Published in: Arthritis Rheum
December 2012

OBJECTIVE: Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the presence of immunomodulating agents, we prospectively evaluated whether interferon (IFN)-dependent peripheral blood gene and chemokine signatures could serve as sensitive and responsive biomarkers for change in disease activity in adult and juvenile DM. METHODS: Peripheral blood and clinical data were collected from 51 patients with juvenile or adult DM prospectively over 2 study visits. We performed disease activity measurements and calculated whole-blood type I IFN gene and chemokine scores. We also measured serum levels of other proinflammatory cytokines, including interleukin-6 (IL-6). RESULTS: Changes in juvenile and adult DM global disease activity correlated positively and significantly with changes in the type I IFN gene score before adjustment for medication use (r = 0.33, P = 0.023) and with changes in the IFN chemokine score before and after adjustment for medication use (r = 0.53, P < 0.001 and r = 0.50, P < 0.001, respectively). Changes in muscle and extramuscular visual analog scale (VAS) scores correlated positively with changes in IFN gene and chemokine scores (P = 0.002, P < 0.001, P = 0.095, P < 0.001). Serum levels of IL-6, IL-8, and tumor necrosis factor α (TNFα) correlated positively with changes in global, muscle, and extramuscular VAS scores (P < 0.05). CONCLUSION: Our findings suggest that changes in type I IFN gene and chemokine scores as well as in levels of IL-6, IL-8, and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunomodulating agents.

Duke Scholars

Published In

Arthritis Rheum

DOI

EISSN

1529-0131

Publication Date

December 2012

Volume

64

Issue

12

Start / End Page

4078 / 4086

Location

United States

Related Subject Headings

  • Young Adult
  • Up-Regulation
  • Tumor Necrosis Factor-alpha
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Retrospective Studies
  • Prospective Studies
  • Middle Aged
  • Male
  • Longitudinal Studies
 

Citation

APA
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Reed, A. M., Peterson, E., Bilgic, H., Ytterberg, S. R., Amin, S., Hein, M. S., … Gillespie, E. B. (2012). Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. Arthritis Rheum, 64(12), 4078–4086. https://doi.org/10.1002/art.34659
Reed, Ann M., Erik Peterson, Hatice Bilgic, Steven R. Ytterberg, Shreyasee Amin, Molly S. Hein, Cynthia S. Crowson, Floranne Ernste, and Emily Baechler Gillespie. “Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.Arthritis Rheum 64, no. 12 (December 2012): 4078–86. https://doi.org/10.1002/art.34659.
Reed AM, Peterson E, Bilgic H, Ytterberg SR, Amin S, Hein MS, et al. Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. Arthritis Rheum. 2012 Dec;64(12):4078–86.
Reed, Ann M., et al. “Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.Arthritis Rheum, vol. 64, no. 12, Dec. 2012, pp. 4078–86. Pubmed, doi:10.1002/art.34659.
Reed AM, Peterson E, Bilgic H, Ytterberg SR, Amin S, Hein MS, Crowson CS, Ernste F, Gillespie EB. Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. Arthritis Rheum. 2012 Dec;64(12):4078–4086.
Journal cover image

Published In

Arthritis Rheum

DOI

EISSN

1529-0131

Publication Date

December 2012

Volume

64

Issue

12

Start / End Page

4078 / 4086

Location

United States

Related Subject Headings

  • Young Adult
  • Up-Regulation
  • Tumor Necrosis Factor-alpha
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Retrospective Studies
  • Prospective Studies
  • Middle Aged
  • Male
  • Longitudinal Studies