Rituximab for successful management of probable pediatric catastrophic antiphospholipid syndrome.
Journal Article (Journal Article)
Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition characterized by small-vessel thrombi and a rapid onset of multiorgan system failure associated with systemic inflammatory response syndrome. Current treatment options include anticoagulants, corticosteroids, plasma exchange, and intravenous immunoglobulin, but these are not always effective. Rituximab, a chimeric anti-CD20 monoclonal antibody, may help eliminate autoreactive B cells and thus limit the rapid inflammatory process involved in CAPS. We describe the use of rituximab in the successful initial management of a probable case of pediatric CAPS.
- Nageswara Rao, AA; Arteaga, GM; Reed, AM; Gloor, JM; Rodriguez, V
- April 2009
Volume / Issue
- 52 / 4
Start / End Page
- 536 - 538
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States