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Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies.

Publication ,  Journal Article
de Padilla, CML; Reed, AM
Published in: Curr Opin Rheumatol
November 2008

PURPOSE OF REVIEW: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have specialized roles in IIM. Here, we will discuss the role of dendritic cells in the induction of adaptive immune response in IIM and review the recent literature addressing the role of dendritic cells in the cause and pathogenesis of inflammatory myopathies. RECENT FINDINGS: Different subsets of immature and mature dendritic cells have been recently identified in skeletal muscle in IIM. Dendritic cells present in inclusion body myositis and polymyositis are primarily myeloid dendritic cells. In contrast, plasmacytoid dendritic cells, a subset of dendritic cells and considered the main source of the interferon-alpha/beta (IFN-alpha/beta), have been found abundantly in muscle tissue of adult dermatomyositis and juvenile dermatomyositis. SUMMARY: Dendritic cells are associated with the chronic infiltration of mononuclear cells in the inflammatory muscle tissue of IIM patients. Increasing evidences point out that dendritic cells are not only crucially involved in the initiation of anti-self immune response but are also essential for the maintenance of autoimmune lesions in inflammatory myopathies.

Duke Scholars

Published In

Curr Opin Rheumatol

DOI

EISSN

1531-6963

Publication Date

November 2008

Volume

20

Issue

6

Start / End Page

669 / 674

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Polymyositis
  • Myositis, Inclusion Body
  • Myositis
  • Muscle, Skeletal
  • Interferon Type I
  • Humans
  • Dermatomyositis
  • Dendritic Cells
  • Cytokines
 

Citation

APA
Chicago
ICMJE
MLA
NLM
de Padilla, C. M. L., & Reed, A. M. (2008). Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. Curr Opin Rheumatol, 20(6), 669–674. https://doi.org/10.1097/BOR.0b013e3283157538
Padilla, Consuelo M López de, and Ann M. Reed. “Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies.Curr Opin Rheumatol 20, no. 6 (November 2008): 669–74. https://doi.org/10.1097/BOR.0b013e3283157538.
de Padilla CML, Reed AM. Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2008 Nov;20(6):669–74.
de Padilla, Consuelo M. López, and Ann M. Reed. “Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies.Curr Opin Rheumatol, vol. 20, no. 6, Nov. 2008, pp. 669–74. Pubmed, doi:10.1097/BOR.0b013e3283157538.
de Padilla CML, Reed AM. Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2008 Nov;20(6):669–674.

Published In

Curr Opin Rheumatol

DOI

EISSN

1531-6963

Publication Date

November 2008

Volume

20

Issue

6

Start / End Page

669 / 674

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Polymyositis
  • Myositis, Inclusion Body
  • Myositis
  • Muscle, Skeletal
  • Interferon Type I
  • Humans
  • Dermatomyositis
  • Dendritic Cells
  • Cytokines