Immunogenetic associations in childhood dermatomyositis.
Journal Article (Review)
Childhood dermatomyositis is a multisystem autoimmune disease characterized by acute and chronic inflammatory infiltrate and vasculitis seen primarily in skin and muscle. The disease occurs in genetically susceptible individuals with a yet undescribed environmental trigger. Genetic associations in this disease demonstrate disease susceptibility as well as chronicity and severity and likely play a role in disease pathogenesis. The majority of the associations to date have been seen with the HLA alleles, with additional immune responsive and influential genes being increasingly investigated.
Full Text
Duke Authors
Cited Authors
- Reed, AM
Published Date
- June 2000
Published In
Volume / Issue
- 2 / 3
Start / End Page
- 212 - 215
PubMed ID
- 11123061
Pubmed Central ID
- 11123061
International Standard Serial Number (ISSN)
- 1523-3774
Digital Object Identifier (DOI)
- 10.1007/s11926-000-0081-z
Language
- eng
Conference Location
- United States