Immunogenetic associations in childhood dermatomyositis.

Journal Article (Journal Article;Review)

Childhood dermatomyositis is a multisystem autoimmune disease characterized by acute and chronic inflammatory infiltrate and vasculitis seen primarily in skin and muscle. The disease occurs in genetically susceptible individuals with a yet undescribed environmental trigger. Genetic associations in this disease demonstrate disease susceptibility as well as chronicity and severity and likely play a role in disease pathogenesis. The majority of the associations to date have been seen with the HLA alleles, with additional immune responsive and influential genes being increasingly investigated.

Full Text

Duke Authors

Cited Authors

  • Reed, AM

Published Date

  • June 2000

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 212 - 215

PubMed ID

  • 11123061

International Standard Serial Number (ISSN)

  • 1523-3774

Digital Object Identifier (DOI)

  • 10.1007/s11926-000-0081-z


  • eng

Conference Location

  • United States