Familial dermatomyositis.

Journal Article (Journal Article;Review)

Susceptibility, response to therapy, prognosis, and natural history of connective tissue diseases are variably linked to histocompatibility antigens (HLA), although the precise role that such genes play is still not clear. In juvenile dermatomyositis (JDMS) there are few reports of both concordance and discordance in identical twins and occurrence in more than one family member. To further document the familial occurrence of JDMS, we describe 2 sisters, one with classical JDMS and the other with amyopathic dermatomyositis. The 2 patients were shown to share the HLA-DQA1*0501 allele, known to be associated with susceptibility to JDMS.

Full Text

Duke Authors

Cited Authors

  • Plamondon, S; Dent, PB; Reed, AM

Published Date

  • December 1999

Published In

Volume / Issue

  • 26 / 12

Start / End Page

  • 2691 - 2692

PubMed ID

  • 10606384

International Standard Serial Number (ISSN)

  • 0315-162X


  • eng

Conference Location

  • Canada