Early-Life State-of-Residence Characteristics and Later Life Hypertension, Diabetes, and Ischemic Heart Disease.


Journal Article

We examined how state characteristics in early life are associated with individual chronic disease later in life.We assessed early-life state of residence using the first 3 digits of social security numbers from blue- and white-collar workers from a US manufacturing company. Longitudinal data were available from 1997 to 2012, with 305 936 person-years of observation. Disease was assessed using medical claims. We modeled associations using pooled logistic regression with inverse probability of censoring weights.We found small but statistically significant associations between early-state-of-residence characteristics and later life hypertension, diabetes, and ischemic heart disease. The most consistent associations were with income inequality, percentage non-White, and education. These associations were similar after statistically controlling for individual socioeconomic and demographic characteristics and current state characteristics.Characteristics of the state in which an individual lives early in life are associated with prevalence of chronic disease later in life, with a strength of association equivalent to genetic associations found for these same health outcomes.

Full Text

Duke Authors

Cited Authors

  • Rehkopf, DH; Eisen, EA; Modrek, S; Mokyr Horner, E; Goldstein, B; Costello, S; Cantley, LF; Slade, MD; Cullen, MR

Published Date

  • August 2015

Published In

Volume / Issue

  • 105 / 8

Start / End Page

  • 1689 - 1695

PubMed ID

  • 26066927

Pubmed Central ID

  • 26066927

Electronic International Standard Serial Number (EISSN)

  • 1541-0048

International Standard Serial Number (ISSN)

  • 0090-0036

Digital Object Identifier (DOI)

  • 10.2105/ajph.2014.302547


  • eng