Acyclic cucurbit[n]uril-type molecular containers bind neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo.


Journal Article

Be my guest: two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats.

Full Text

Duke Authors

Cited Authors

  • Ma, D; Zhang, B; Hoffmann, U; Sundrup, MG; Eikermann, M; Isaacs, L

Published Date

  • November 5, 2012

Published In

Volume / Issue

  • 51 / 45

Start / End Page

  • 11358 - 11362

PubMed ID

  • 23047893

Pubmed Central ID

  • 23047893

Electronic International Standard Serial Number (EISSN)

  • 1521-3773

Digital Object Identifier (DOI)

  • 10.1002/anie.201206031


  • eng

Conference Location

  • Germany