Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.

Published

Journal Article

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200  mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2  hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.

Full Text

Duke Authors

Cited Authors

  • Hoffmann, U; Lee, JH; Qin, T; Eikermann-Haerter, K; Ayata, C

Published Date

  • July 2011

Published In

Volume / Issue

  • 31 / 7

Start / End Page

  • 1578 - 1582

PubMed ID

  • 21505480

Pubmed Central ID

  • 21505480

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

Digital Object Identifier (DOI)

  • 10.1038/jcbfm.2011.50

Language

  • eng

Conference Location

  • United States