Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations.
Journal Article
Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We, therefore, tested gabapentin on PIDs and stroke outcome. Gabapentin pretreatment (200 mg/kg, intravenously) reduced the infarct volume by 23% after transient focal ischemia in mice. However, the frequency and duration of PIDs were not suppressed when recorded for 2 hours during ischemia, suggesting that gabapentin reduces infarct volume independent of PID suppression.
Full Text
Duke Authors
Cited Authors
- Hoffmann, U; Lee, JH; Qin, T; Eikermann-Haerter, K; Ayata, C
Published Date
- July 2011
Published In
Volume / Issue
- 31 / 7
Start / End Page
- 1578 - 1582
PubMed ID
- 21505480
Pubmed Central ID
- 21505480
Electronic International Standard Serial Number (EISSN)
- 1559-7016
Digital Object Identifier (DOI)
- 10.1038/jcbfm.2011.50
Language
- eng
Conference Location
- United States