Oxcarbazepine does not suppress cortical spreading depression.

Published

Journal Article

BACKGROUND: Cortical spreading depression is the electrophysiological substrate of migraine aura, and may trigger headache. Recently, chronic treatment with five migraine prophylactic drugs was shown to suppress cortical spreading depression, implicating spreading depression as a common therapeutic target in migraine prophylaxis. MATERIALS AND METHODS: In order to assess the negative predictive value of spreading depression susceptibility as a preclinical drug screening tool, we tested oxcarbazepine, an anti-epileptic ineffective in migraine prophylaxis. Valproate served as the positive control. Cortical spreading depression susceptibility was measured in rats using topical KCl or electrical stimulation. RESULTS: Oxcarbazepine did not suppress spreading depression either after a single dose or after daily treatment for 5 weeks. As previously shown, valproate suppressed spreading depression susceptibility after chronic dosing, while a single dose was ineffective. CONCLUSIONS: These data provide further support for spreading depression as a relevant target in migraine prophylaxis, and demonstrate the predictive utility of employed spreading depression models.

Full Text

Duke Authors

Cited Authors

  • Hoffmann, U; Dileköz, E; Kudo, C; Ayata, C

Published Date

  • April 2011

Published In

Volume / Issue

  • 31 / 5

Start / End Page

  • 537 - 542

PubMed ID

  • 21059627

Pubmed Central ID

  • 21059627

Electronic International Standard Serial Number (EISSN)

  • 1468-2982

Digital Object Identifier (DOI)

  • 10.1177/0333102410388433

Language

  • eng

Conference Location

  • England