Gabapentin suppresses cortical spreading depression susceptibility.

Journal Article (Journal Article)

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats. Gabapentin, 100 or 200 mg/kg, elevated the electrical threshold for CSD and diminished recurrent CSDs evoked by topical KCl, when administered 1 hour before testing. With its favorable safety and tolerability profile, gabapentin may have a role in suppression of injury depolarizations in stroke, intracranial hemorrhage, and traumatic brain injury.

Full Text

Duke Authors

Cited Authors

  • Hoffmann, U; Dileköz, E; Kudo, C; Ayata, C

Published Date

  • September 2010

Published In

Volume / Issue

  • 30 / 9

Start / End Page

  • 1588 - 1592

PubMed ID

  • 20588320

Pubmed Central ID

  • PMC2949257

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

Digital Object Identifier (DOI)

  • 10.1038/jcbfm.2010.92


  • eng

Conference Location

  • United States