Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures.

Journal Article (Journal Article)

The low Mg2+ model of epilepsy in organotypic hippocampal slice cultures is used to elucidate the mechanism underlying neuronal cell death following sustained epileptiform activity. However, the high oxygen tension of 95% widely used in this model is capable of inducing neuronal cell death by itself. Here we demonstrate that even under normoxic conditions 1h of epileptiform activity induced neuronal cell death as assessed by Propidium Iodide uptake. We conclude that hyperoxia is not essential for status epilepticus induced neuronal cell death in this model.

Full Text

Duke Authors

Cited Authors

  • Pomper, JK; Hoffmann, U; Kovács, R; Gabriel, S; Heinemann, U

Published Date

  • March 2004

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 61 - 65

PubMed ID

  • 15135168

International Standard Serial Number (ISSN)

  • 0920-1211

Digital Object Identifier (DOI)

  • 10.1016/j.eplepsyres.2004.03.002


  • eng

Conference Location

  • Netherlands