Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures.
Published
Journal Article
The low Mg2+ model of epilepsy in organotypic hippocampal slice cultures is used to elucidate the mechanism underlying neuronal cell death following sustained epileptiform activity. However, the high oxygen tension of 95% widely used in this model is capable of inducing neuronal cell death by itself. Here we demonstrate that even under normoxic conditions 1h of epileptiform activity induced neuronal cell death as assessed by Propidium Iodide uptake. We conclude that hyperoxia is not essential for status epilepticus induced neuronal cell death in this model.
Full Text
Duke Authors
Cited Authors
- Pomper, JK; Hoffmann, U; Kovács, R; Gabriel, S; Heinemann, U
Published Date
- March 2004
Published In
Volume / Issue
- 59 / 1
Start / End Page
- 61 - 65
PubMed ID
- 15135168
Pubmed Central ID
- 15135168
International Standard Serial Number (ISSN)
- 0920-1211
Digital Object Identifier (DOI)
- 10.1016/j.eplepsyres.2004.03.002
Language
- eng
Conference Location
- Netherlands