Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures.
Journal Article
Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic, and excitotoxic stress. In this study evoked extracellular field potentials (FP) were used to investigate the effect of EPO on synaptic transmission in hippocampal slice cultures. EPO treated cultured slices (40 units/ml for 48 h) showed significantly increased FP during and following oxygen and glucose deprivation compared with untreated control slices. The addition of the Jak2 inhibitor AG490 (50 microM for 48 h) blocked the EPO effect. These data suggest that EPO improves synaptic transmission during and following ischemia in hippocampal slice cultures.
Full Text
Duke Authors
Cited Authors
- Weber, A; Maier, RF; Hoffmann, U; Grips, M; Hoppenz, M; Aktas, AG; Heinemann, U; Obladen, M; Schuchmann, S
Published Date
- December 27, 2002
Published In
Volume / Issue
- 958 / 2
Start / End Page
- 305 - 311
PubMed ID
- 12470866
Pubmed Central ID
- 12470866
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/s0006-8993(02)03604-1
Language
- eng
Conference Location
- Netherlands