Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures.

Journal Article

Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic, and excitotoxic stress. In this study evoked extracellular field potentials (FP) were used to investigate the effect of EPO on synaptic transmission in hippocampal slice cultures. EPO treated cultured slices (40 units/ml for 48 h) showed significantly increased FP during and following oxygen and glucose deprivation compared with untreated control slices. The addition of the Jak2 inhibitor AG490 (50 microM for 48 h) blocked the EPO effect. These data suggest that EPO improves synaptic transmission during and following ischemia in hippocampal slice cultures.

Full Text

Duke Authors

Cited Authors

  • Weber, A; Maier, RF; Hoffmann, U; Grips, M; Hoppenz, M; Aktas, AG; Heinemann, U; Obladen, M; Schuchmann, S

Published Date

  • December 2002

Published In

Volume / Issue

  • 958 / 2

Start / End Page

  • 305 - 311

PubMed ID

  • 12470866

Electronic International Standard Serial Number (EISSN)

  • 1872-6240

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/s0006-8993(02)03604-1

Language

  • eng