Folate fortification of rice by metabolic engineering.
Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement.
Storozhenko, S; De Brouwer, V; Volckaert, M; Navarrete, O; Blancquaert, D; Zhang, G-F; Lambert, W; Van Der Straeten, D
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