Folate fortification of rice by metabolic engineering.

Journal Article (Journal Article)

Rice, the world's major staple crop, is a poor source of essential micronutrients, including folates (vitamin B9). We report folate biofortification of rice seeds achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. We obtained a maximal enhancement as high as 100 times above wild type, with 100 g of polished raw grains containing up to four times the adult daily folate requirement.

Full Text

Duke Authors

Cited Authors

  • Storozhenko, S; De Brouwer, V; Volckaert, M; Navarrete, O; Blancquaert, D; Zhang, G-F; Lambert, W; Van Der Straeten, D

Published Date

  • November 2007

Published In

Volume / Issue

  • 25 / 11

Start / End Page

  • 1277 - 1279

PubMed ID

  • 17934451

International Standard Serial Number (ISSN)

  • 1087-0156

Digital Object Identifier (DOI)

  • 10.1038/nbt1351


  • eng

Conference Location

  • United States