Renal function outcomes for multifocal renal neoplasms managed by radiofrequency ablation.

Published

Journal Article

PURPOSE: To evaluate renal function changes related to radiofrequency ablation (RFA) for the treatment of multifocal renal neoplasms. METHODS: This is an institutional review board-approved, Health Insurance Portability and Accountability Act compliant retrospective study of all patients treated with computed tomography guided RFA for multifocal renal neoplasms at one institution. Fifty-seven subjects, mean age 70 (range 37-88) years, underwent RFA of 169 renal neoplasms (average size 2.0 cm). Subjects had between 2 and 8 (mean 2.96) neoplasms ablated. Estimated glomerular filtration rate (eGFR) was measured before and after RFA. Complications related to RFA were recorded. RESULTS: eGFR decreased on average of 4.4 % per tumor treated and 6.7 % per ablation session (average 1.76 tumors treated per session). For subjects with the largest neoplasm measuring >3 cm, eGFR decreased an average of 14.5 % during the course of their treatment. If the largest neoplasm measured 2-3 cm, eGFR decreased an average of 7.7 %, and if the largest neoplasm measured <2 cm, eGFR decreased an average of 3.8 %. Subjects with reduced baseline renal function were more likely to have a greater decline in eGFR after RFA. There was a minor complication rate of 6.3 % (6 of 96 sessions), none of which required treatment, and a major complication rate of 4.2 % (4 of 96 sessions). CONCLUSION: RFA for the treatment of multifocal renal neoplasms results in mild decline of renal function.

Full Text

Duke Authors

Cited Authors

  • Gupta, P; Allen, BC; Chen, MY; Childs, DD; Kota, G; Zagoria, RJ

Published Date

  • October 2013

Published In

Volume / Issue

  • 36 / 5

Start / End Page

  • 1329 - 1335

PubMed ID

  • 23361116

Pubmed Central ID

  • 23361116

Electronic International Standard Serial Number (EISSN)

  • 1432-086X

Digital Object Identifier (DOI)

  • 10.1007/s00270-013-0563-9

Language

  • eng

Conference Location

  • United States